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Am. J. Trop. Med. Hyg., 79(5), 2008, pp. 715-718
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

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CASE REPORT


Post-Kala-Azar Dermal Leishmaniasis in an HIV-1–Infected Woman: Recovery after Amphotericin B Following Failure of Oral Miltefosine

Monica Guffanti*, Giovanni Gaiera, Simona Bossolasco, Norberto Ceserani, Deborah Ratti, Paola Cinque, Flavia Salmaso, Nicola Gianotti, AND Adriano Lazzarin
Clinic of Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy; STD Centre-Institute of Dermatological Sciences, IRCCS Ospedale Maggiore, Milan, Italy; Università Vita-Salute San Raffaele, Milan, Italy

 

ABSTRACT

We describe a case of post-kala-azar dermal leishmaniasis occurring after diagnosis of visceral leishmaniasis in an HIV-1–infected woman. The skin lesions did not recover after treatment with oral miltefosine at 100 mg/day for five cycles of 28 days but responded to treatment with liposomal amphotericin B.

Received December 25, 2007. Accepted for publication April 8, 2008.

Acknowledgments: The authors thank the patient for giving them the opportunity to publish her case. Furthermore, the authors thank Dr L Bossi from the Laboratory of Parasitology, IRCCS Ospedale Maggiore, Milano, and Drs M Giola and G Ferraro from the Department of Infectious Diseases, Ospedale di Circolo-Fondazione Macchi, Varese, for collaboration on this report.

Disclosure: NG received support for research and educational programs by Gilead Sciences.

* Address correspondence to Monica Guffanti, Clinic of Infectious Diseases, San Raffaele Scientific Institute, Via Stamira d’Ancona 20, 20127 Milan, Italy. E-mail: guffanti.monica{at}hsr.it

Author’ s addresses: Monica Guffanti, Giovanni Gaiera, Simona Bossolasco, Norberto Ceserani, Deborah Ratti, Paola Cinque, and Nicola Gianotti, Clinic of Infectious Diseases, San Raffaele Scientific Institute, Via Stamira d’Ancona 20, 20127 Milan, Italy, Tel: 39-02264-37939, Fax: 39-02264-37030, E-mails: guffanti.monica{at}hsr.it, giovanni.gaiera{at}libero.it, bossolasco.simona{at}hsr.it, ceserani.norberto{at}hsr.it, ratti.deborah{at}hsr.it, cinque.paola{at}hsr.it, and gianotti.nicola{at}hsr.it. Flavia Salmaso, STD Centre, Institute of Dermatological Sciences, IRCCS Ospedale Maggiore, Via Pace 9, 20122 Milan, Italy, E-mail: flaviasalmaso{at}hotmail.com. Adriano Lazzarin, Clinic of Infectious Diseases, San Raffaele Scientific Institute, Via Stamira d’Ancona 20, 20127 Milan, Italy and Università Vita-Salute San Raffaele, Via Olgettina 58, 20132 Milan, Italy, E-mail: lazzarin.adriano{at}hsr.it.






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Copyright © 2008 by the American Society of Tropical Medicine and Hygiene.