| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Bangladesh experienced severe flooding and diarrheal epidemics in 2007. We compared flood data from 2007 with 2004 and 1998 for diarrheal patients attending the ICDDR,B hospital in Dhaka. In 2007, Vibrio cholerae O1 (33%), rotavirus (12%), and enterotoxigenic Escherichia coli (ETEC) (12%) were most prevalent. More severe dehydration was seen in 2007 compared with 2004 and 1998 (P < 0.001). In 2007, V. cholerae O1 Inaba (52%) and Ogawa (48%) were seen, whereas in 2004 and 1998 it was primarily Inaba and the Ogawa types, respectively (P < 0.001). In 2007, 51% of ETEC produced the heat labile toxin (LT) (P < 0.001 compared with 2004), 22% expressed the heat stable (ST) (P < 0.001), and 27% were ST/LT positive (P = 0.231). The CS7 colonization factor (CF) was the most prevalent in 2007 (20% compared with 6% in 2004; P = 0.05). Our findings demonstrate alterations in clinical features and phenotypic changes of major bacterial pathogens in the recent Bangladesh flood.
Received July 1, 2008. Accepted for publication August 4, 2008.
Financial support: This research was supported by ICDDR,B and by the following grants: U01 AI058935 (S.B.C.); RO3 AI063079 (FQ); R01 AI40725 (E.T.R.); and the Swedish Agency for Research and Economic Cooperation (Sida-SAREC; Grant 2004-0578) (F.Q). Aaron Harris is recipient of the Fogarty/Ellison Fellowship in Global Health awarded by the Fogarty International Center at the National Institutes of Health (D43 TW005572).
* Address correspondence to Firdausi Qadri, Laboratory of Immunology, Laboratory Sciences Division, ICDDR,B, 68, Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka 1212, Bangladesh. E-mail: fqadri{at}mail.icddrb.org
AMH and FC contributed equally to the work.
Authors’ addresses: Aaron M. Harris, Tufts University School of Medicine, Public Health and Family Medicine, Medical and Vet-136 Harrison Avenue, Boston, MA 02111, Fogarty Ellison Fellow at the International Centre for Diarrhoeal Disease Research, Bangladesh, Tel: 617-636-6941, Fax: 617-636-4017, E-mail: aaron.harris{at}tufts.edu. Fahima Chowdhury, Ashraful Islam Khan, and Abu S. G. Faruque, Clinical Sciences Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Mohakhali, Dhaka 1212, Tel: 8802-860523-32, Fax: 8802-8823116, E-mails: fchowdhury{at}icddrb.org, ashrafk{at}icddrb.org, and gfaruque{at}icddrb.org. Yasmin Ara Begum, Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Mohakhali, Dhaka 1212, Tel: 8802-860523-32, Fax: 8802-8823116, E-mail: yasmin{at}icddrb.org. Ann-Mari Svennerholm, Department of Medical Microbiology and Immunology Institute of Biomedicine, The Sahlgrenska Academy at Gothenburg University, Medicinaregaten 7A,S-40530, Goteborg, Box 435, Sweden, Tel: 4631-7736-202, Fax: 4631-7736-205, E-mail: ann-mari.Svennerholm{at}microbio.gu.se. Jason B. Harris, Edward T. Ryan, and Stephen B. Calderwood, Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit St., Boston MA 02481, Tel: 617-726-3812, Fax: 617-726-7416, E-mails: jbharris{at}partners.org, etryan{at}partners.org, and scalderwood{at}partners.org. Alejandro Cravioto, Executive Director’s Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Mohakhali, Dhaka 1212, Tel: 8802-8823031, Fax: 8802-8823116, E-mail: acravioto{at}icddrb.org. Firdausi Qadri, Laboratory of Immunology, Laboratory Sciences Division, ICDDR,B, 68, Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka 1212, Bangladesh, E-mail: fqadri{at}mail.icddrb.org.
This article has been cited by other articles:
|
|
 |
|
  G. M. Glenn, D. H. Francis, and E. M. Danielsen Toxin-Mediated Effects on the Innate Mucosal Defenses: Implications for Enteric Vaccines Infect. Immun., December 1, 2009; 77(12): 5206 - 5215. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
