AJTMH Tropical Medicine and Hygiene News
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 79(4), 2008, pp. 571-578
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Tefé-Silva, C.
Right arrow Articles by Ramos, S. G.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tefé-Silva, C.
Right arrow Articles by Ramos, S. G.

Interference of Dexamethasone in the Pulmonary Cycle of Strongyloides venezuelensis in Rats

Cristiane Tefé-Silva, Daniela I. Souza, Marlene T. Ueta, Elaine M. Floriano, Lúcia H. Faccioli, AND Simone G. Ramos*
Departamento de Patologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil; Departamento de Parasitologia, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil; Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil

The aim of this study was to investigate the interference of a daily treatment of dexamethasone in the pulmonary cycle of Strongyloides venezuelensis infection in rats. Three principal effects were found: 1) increased alveolar hemorrhagic inflammation provoked by the passage of larvae into alveolar spaces; 2) significant decrease of eosinophil and mast cell migration to the axial septum of the lungs; and 3) impaired formation of the reticular fiber network, interfering with granuloma organization. This study showed that the use of drugs with immunomodulatory actions, such as dexamethasone, in addition to interfering with the morbidity from the pulmonary cycle of S. venezuelensis infection, may contribute to showing the mechanisms involved in its pathogenesis.

Received May 9, 2008. Accepted for publication July 17, 2008.

Acknowledgments: The authors thank Abel Dorigan Neto, Carlos A. Sorgi, João B. A. Oliveira, and Maria Elena Riul for excellent technical assistance and Julio C. Matos for photography assistance.

Financial support: C.T.S. received a scholarship of Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. S.G.R. and L.H.F. are investigators of Conselho Nacional de Desenvolvimento Científico e Tecnológico.

* Address correspondence to Simone G. Ramos, Departamento de Patologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo. Av. Bandeirantes, 3900, 14049-900, Ribeirão Preto, São Paulo, Brazil. E-mail: sgramos{at}fmrp.usp.br

Authors’ addresses: Cristiane Tefé-Silva, Elaine M. Floriano, and Simone G. Ramos, Departamento de Patologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Avenida Bandeirantes, 3900, 14049-900, Ribeirão Preto, São Paulo, Brazil, Tel/Fax: 55-16-36023341, E-mails: cristefe{at}usp.br, floriano{at}fmrp.usp.br, and sgramos{at}fmrp.usp.br. Daniela I. Souza, E-mail: daniela_i_souza{at}bd.com. Marlene T. Ueta, Departamento de Parasitologia, Instituto de Biologia, Universidade Estadual de Campinas, 6109, 13073-970 Campinas, São Paulo, Brazil, Tel/Fax: 55-19-35216301, E-mail: mtu{at}unicamp.br. Lúcia H. Faccioli, Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil, Tel: 55-16-36024303, E-mail: faccioli{at}fcfrp.usp.br.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by the American Society of Tropical Medicine and Hygiene.