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Am. J. Trop. Med. Hyg., 79(4), 2008, pp. 541-544
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


Mycobacterial Clearance from Sputum Is Delayed during the First Phase of Treatment in Patients with Diabetes

Blanca I. Restrepo, Susan P. Fisher-Hoch*, Brian Smith, Sangchoon Jeon, Mohammad H. Rahbar, Joseph B. McCormick the Nuevo Santander Tuberculosis Trackers
Division of Epidemiology, University of Texas School of Public Health, Brownsville, Texas; Texas Department of State and Health Services Region, Harlingen, Texas; Department of Epidemiology, College of Human Medicine, Michigan State University, East Lansing, Michigan; Division of Epidemiology, University of Texas School of Public Health and The Center for Clinical and Translational Sciences at The University of Texas Health Science Center at Houston, Houston, Texas

 

ABSTRACT

Although type 2 diabetes (DM) is a recognized risk factor for development of tuberculosis (TB), the impact on treatment is unclear. Among the few published reports, some suggest that mycobacterial clearance during treatment is delayed in TB patients with DM. Using survival analysis on data from 469 culture-positive TB patients retrospectively identified in south Texas, we found DM to be an independent risk factor for a 5-day delay in mycobacterial clearance within the first 60 days of treatment.

Received November 13, 2007. Accepted for publication June 26, 2008.

Acknowledgments: The authors thank the members of the NSTT (www.nstt.info) in south Texas and the members of the Division of Tuberculosis Elimination at the Texas Department of State Health Services who contributed to this study by collecting and entering data and by processing and reporting routine microbiological reports. We also acknowledge the statistical consulting work performed on this paper through a subcontract with Universal Statistical Technology and Training (USTAT), based in Okemos, Michigan.

Financial support: This study was supported by NIAID 1 R21 AIO56207-01 and by the Hispanic Health Research Center EXPORT Grant NIHMHD P20 MD000170 020.

* Address correspondence to Susan P. Fisher-Hoch, Division of Epidemiology, University of Texas School of Public Health, Brownsville, 80 Fort Brown, Brownsville, TX 78520. E-mail: susan.p.fisher-hoch{at}utb.edu

Authors’ addresses: Blanca I. Restrepo, University of Texas Health Science Center Houston-School of Public Health, University of Texas at Brownsville, 80 Fort Brown, SPH Bldg, Brownsville, TX 78520, Tel: 956-882-5172, Fax: 956-882-5152, E-mail: Blanca.I.Restrepo{at}utb.edu. Susan P. Fisher-Hoch, University of Texas Health Science Center Houston-School of Public Health, University of Texas at Browns-ville, 80 Fort Brown, SPH Bldg, Brownsville, TX 78520, Tel: 956-882-5167, Fax: 956-882-5152, E-mail: susan.p.fisher-hoch{at}utb.edu. Brian Smith, Texas Department of State and Health Services, Region 11, 601 W. Sesame Dr., Harlingen, TX 78550, Tel: 956-444-3202, Fax: 956-444-3298, E-mail: Brian.Smith{at}dshs.state.tx.us. Shangchoon Jeon, Nursing Research Center, 426B W Fee Hall, Michigan State University, East Lansing, MI 48823, Tel: 517-355-1851, Fax: 517-355-5002, E-mail: Sangchoon.Jeon{at}hc.msu.edu. Mohammed H. Rahbar, Center for Clinical and Translational Sciences, UT Professional Building, Room 1100.21, 6410 Fannin Street, Houston, TX 77030, Tel: 713-500-7901, Fax: 713-500-0766, E-mail: Mohammad.H.Rahbar{at}uth.tmc.edu. Joseph B. McCormick, University of Texas Health Science Center Houston-School of Public Health, University of Texas at Brownsville, 80 Fort Brown, SPH Bldg, Brownsville, TX 78520, Tel: 956-882-5166, Fax: 956-882-5152, E-mail: joseph.b. mccormick{at}utb.edu.






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