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Am. J. Trop. Med. Hyg., 79(3), 2008, pp. 427-434
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

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Rural Triatoma rubrovaria from Southern Brazil Harbors Trypanosoma cruzi of Lineage IIc

Luciamáre P. A. Martins, Arlei Marcili, Roberto E. P. Castanho, Altino L. S. Therezo, Janaína C. P. de Oliveira, Rodrigo B. Suzuki, Marta M. G. Teixeira, João A. da Rosa, AND Márcia A. Sperança*
Discipline of Parasitology, Marília Medical School, São Paulo, Brazil; Department of Parasitology, Institute of Medical Sciences, University of São Paulo, São Paulo, Brazil; Discipline of Pathology, Marília Medical School, São Paulo, Brazil; Department of Biological Sciences, School of Pharmaceutical Sciences, São Paulo State University, São Paulo, Brazil; Discipline of Molecular Biology, Marília Medical School, São Paulo, Brazil

Triatoma infestans, the main vector of Chagas disease, has nearly been eliminated from Brazil. Nevertheless, other triatominae species are involved in the domiciliation process, including Triatoma rubrovaria in Rio Grande do Sul State (RS). Previous studies showed that 1.6% of the T. rubrovaria specimens collected at the rural district of Quaraí, RS, were naturally infected by Trypanosoma cruzi. In this study, five T. cruzi isolates obtained from infected triatomines were characterized molecularly and biologically. Genotyping of the T. cruzi isolates showed that they belong to lineage IIc of T. cruzi (TCIIc). Biological characterization showed miotropism and myositis during acute and chronic phases of infection, respectively. Virulence and mortality rates were variable among isolates. To our knowledge, this study corresponds to the first characterization of T. cruzi isolates from T. rubrovaria and the first description of TCIIc in the sylvatic cycle of T. cruzi from the southern region of Brazil.

Received December 12, 2007. Accepted for publication May 20, 2008.

Financial support: This work was supported by Fundação para o Desenvolvimento da UNESP (FUNDUNESP), Secretaria de Saúde do Estado do Rio Grande do Sul, CNPq, and FAPESP.

* Address correspondence to Márcia A. Sperança, Discipline of Molecular Biology, Marilia Medical School, Av. Monte Carmelo 800, CEP 17519f-030, Marília SP, Brazil. E-mail: speranca{at}famema.br

Authors’ addresses: Luciamá re P. A. Martins, Roberto E. P. Castanho, and Janaína C. P. de Oliveira, Discipline of Parasitology, Marília Medical School, Av. Monte Carmelo, 800, CEP 17519-030, Marília, São Paulo, Brazil, Tel: 55-14-3433-1744, E-mails: luciapam{at}famema.br and castanho{at}famema.br. Arlei Marcili and Marta M. G. Teixeira, Department of Parasitology, Institute of Medical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1374, CEP 05508-900, São Paulo, Brazil, Tel: 55-11-3091-7331, E-mails: amarcili{at}usp.br and mmgteix{at}icb.usp.br. Altino L. S. Therezo, Discipline of Pathology, Marília Medical School, Av. Monte Carmelo, 800, CEP 17519-030, Marília, Sã o Paulo, Brazil, Tel: 55-14-3433-1744, E-mail: altinoth{at}hotmail.com. Rodrigo B. Suzuki and Márcia A. Sperança, Discipline of Molecular Biology, Marilia Medical School, Av. Monte Carmelo 800, CEP 17519-030, Marília, SP, Brazil, Tel: 55-14-3433-1235, Fax: 55-14-3413-4187, E-mails: speranca{at}famema.br and rbsuzuki{at}gmail.com. João A. da Rosa, Department of Parasitology, Pharmaceutical Sciences Faculty, University of the State of São Paulo, Rodovia Araraquara-Jaú Km 01, CEP 14801-902, Caixa postal 502, Araraquara, São Paulo, Brazil, Tel: 55-16-3301-6943, E-mail: rosaja{at}fcfar.unesp.br.






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Copyright © 2008 by the American Society of Tropical Medicine and Hygiene.