AJTMH HINARI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 79(3), 2008, pp. 378-384
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pukrittayakamee, S.
Right arrow Articles by White, N. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pukrittayakamee, S.
Right arrow Articles by White, N. J.
Related Collections
Right arrow Malaria

Effects of Different Antimalarial Drugs on Gametocyte Carriage in P. Vivax Malaria

Sasithon Pukrittayakamee, Mallika Imwong, Pratap Singhasivanon, Kasia Stepniewska, Nicholas J. Day, AND Nicholas J. White*
Department of Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; The Royal Institute, Grand Palace, Bangkok, Thailand; Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, United Kingdom

The gametocytocidal and asexual stage activities of eight antimalarial and eight antibiotic-containing regimens were evaluated in 349 adult patients with P. vivax malaria. Gametocytemia was found in 63% of patients (22% before and 41% after treatment). The median (range) gametocyte clearance time was 24 hours (range, 2–504 hours) and correlated with asexual parasite clearance time (r = 0.52, P < 0.001). Gametocytemia in vivax malaria was more common in patients with admission parasitemia > 10,000/µL and after treatment with drugs which have weak antimalarial activity, and was also associated with an increased rate of vivax reappearance (29.4% versus 14.1%, P = 0.002). Sexual stage activities corresponded with asexual stage activity for all tested regimens. Treatment with potent antimalarial drugs reduces the transmission potential of P. vivax.

Received January 24, 2007. Accepted for publication June 2, 2008.

Financial support: This study was part of the Mahidol-Oxford Tropical Medicine Research Programme funded by the Wellcome Trust of Great Britain.

* Address correspondence to Nicholas J. White, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand. E-mail: nickw{at}tropmedres.ac

Authors’ address: Sasithon Pukrittayakamee, Mallika Imwong, Pratap Singhasivanon, Kasia Stepniewska, Nicholas J. Day, and Nicholas J.White, Department of Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand, Tel: 66-2-354-9172, Fax: 66-2-3549169, E-mail: nickw{at}tropmedres.ac.




This article has been cited by other articles:


Home page
 Am J Trop Med HygHome page
N. Valecha, R. G. W. Pinto, G. D. H. Turner, A. Kumar, S. Rodrigues, N. G. Dubhashi, E. Rodrigues, S. S. Banaulikar, R. Singh, A. P. Dash, et al.
Histopathology of Fatal Respiratory Distress Caused by Plasmodium vivax Malaria
Am J Trop Med Hyg, November 1, 2009; 81(5): 758 - 762.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
M. Beurskens, P. Mens, H. Schallig, D. Syafruddin, P. B. S. Asih, R. Hermsen, and R. Sauerwein
Quantitative Determination of Plasmodium vivax Gametocytes by Real-Time Quantitative Nucleic Acid Sequence-Based Amplification in Clinical Samples
Am J Trop Med Hyg, August 1, 2009; 81(2): 366 - 369.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
J. K. Baird
Resistance to Therapies for Infection by Plasmodium vivax
Clin. Microbiol. Rev., July 1, 2009; 22(3): 508 - 534.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by the American Society of Tropical Medicine and Hygiene.