HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pukrittayakamee, S. Articles by White, N. J. Search for Related Content PubMed PubMed Citation Articles by Pukrittayakamee, S. Articles by White, N. J. Related Collections Malaria

Effects of Different Antimalarial Drugs on Gametocyte Carriage in P. Vivax Malaria

The gametocytocidal and asexual stage activities of eight antimalarial and eight antibiotic-containing regimens were evaluated in 349 adult patients with P. vivax malaria. Gametocytemia was found in 63% of patients (22% before and 41% after treatment). The median (range) gametocyte clearance time was 24 hours (range, 2–504 hours) and correlated with asexual parasite clearance time (r = 0.52, P < 0.001). Gametocytemia in vivax malaria was more common in patients with admission parasitemia > 10,000/µL and after treatment with drugs which have weak antimalarial activity, and was also associated with an increased rate of vivax reappearance (29.4% versus 14.1%, P = 0.002). Sexual stage activities corresponded with asexual stage activity for all tested regimens. Treatment with potent antimalarial drugs reduces the transmission potential of P. vivax.

Received January 24, 2007. Accepted for publication June 2, 2008.

Financial support: This study was part of the Mahidol-Oxford Tropical Medicine Research Programme funded by the Wellcome Trust of Great Britain.

^* Address correspondence to Nicholas J. White, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand. E-mail: nickw{at}tropmedres.ac

Authors’ address: Sasithon Pukrittayakamee, Mallika Imwong, Pratap Singhasivanon, Kasia Stepniewska, Nicholas J. Day, and Nicholas J.White, Department of Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand, Tel: 66-2-354-9172, Fax: 66-2-3549169, E-mail: nickw{at}tropmedres.ac.

This article has been cited by other articles:

				N. Valecha, R. G. W. Pinto, G. D. H. Turner, A. Kumar, S. Rodrigues, N. G. Dubhashi, E. Rodrigues, S. S. Banaulikar, R. Singh, A. P. Dash, et al. Histopathology of Fatal Respiratory Distress Caused by Plasmodium vivax Malaria Am J Trop Med Hyg, November 1, 2009; 81(5): 758 - 762. [Abstract] [Full Text] [PDF]

				M. Beurskens, P. Mens, H. Schallig, D. Syafruddin, P. B. S. Asih, R. Hermsen, and R. Sauerwein Quantitative Determination of Plasmodium vivax Gametocytes by Real-Time Quantitative Nucleic Acid Sequence-Based Amplification in Clinical Samples Am J Trop Med Hyg, August 1, 2009; 81(2): 366 - 369. [Abstract] [Full Text] [PDF]

				J. K. Baird Resistance to Therapies for Infection by Plasmodium vivax Clin. Microbiol. Rev., July 1, 2009; 22(3): 508 - 534. [Abstract] [Full Text] [PDF]