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Am. J. Trop. Med. Hyg., 79(3), 2008, pp. 372-377
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

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Desialylation of Plasma Proteins in Severe Dengue Infection: Possible Role of Oxidative Stress

Soundravally Rajendiran, Hoti Sugeerappa Lakshamanappa*, Bobby Zachariah, AND Selvaraj Nambiar
Department of Molecular Biology and Bioinformatics, Vector Control Research Centre (VCRC), Pondicherry, India; Department of Biochemistry, Jawaharlal Institute of Postgraduate Medicine and Research, Pondicherry, India

Oxidative stress in dengue infection has been suggested. This study was carried out to explore the plasma protein oxidation and its sialic acid content in dengue infection. Thirty-two dengue hemorrhagic fever (DHF), 25 dengue shock syndrome (DSS), 29 dengue fever (DF), and 63 healthy controls were included in this study. The extent of carbonylation, sulphydryl content, and desialylation of plasma protein was estimated in acute phase sample. Significantly higher levels of protein carbonyls and lower levels of sialic acid and sulphydryl groups were found in DHF and DSS compared with DF using one-way analysis of variance. Regression analysis showed that desialylation is dependent on protein carbonyls in DHF/DSS. This study indicates that, in dengue infection, plasma proteins undergo increased levels of desialylation, which can be attributed to the oxidative stress. Future studies on sialylation status of endothelium and platelets can show light into the pathogenesis of the dengue infection.

Received December 29, 2007. Accepted for publication May 13, 2008.

Acknowledgments: The authors thank Dr. M. G. Sridhar, P. Sankar, Dr. Sajita Setia, and Smitha Mariano Koshy for kind help in manuscript preparation and the clinicians of JIPMER for providing a clinical description of patients.

* Address correspondence to S. L. Hoti, Department of Molecular Biology and Bioinformatics, Vector Control Research Centre (VCRC), Pondicherry, India. E-mail: hotigood{at}gmail.com

Authors’ addresses: Soundravally Rajendiran and S.L. Hoti, Department of Molecular Biology and Bioinformatics, Vector Control Research Centre (VCRC), Pondicherry, India, Tel: 00-91-9443602724, Fax: 91-413-227204, E-mail: hotigood{at}gmail.com. Bobby Zachariah and Selvaraj Nambiar, Department of Biochemistry, Jawaharlal Institute of Postgraduate Medicine and Research, Pondicherry, India.






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Copyright © 2008 by the American Society of Tropical Medicine and Hygiene.