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Am. J. Trop. Med. Hyg., 79(3), 2008, pp. 312-318
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

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Ethical, Social, and Cultural Considerations for Site Selection for Research with Genetically Modified Mosquitoes

James V. Lavery*, Laura C. Harrington, AND Thomas W. Scott
Centre for Research on Inner City Health, Centre for Global Health Research, The Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael’s Hospital, Department of Public Health Sciences and Joint Centre for Bioethics, University of Toronto, Toronto, Ontario, Canada; Department of Entomology, Cornell University, Ithaca, New York; Department of Entomology, University of California, Davis, California

Recent advances in technology have made strategies for disease control using genetically modified (GM) vectors more plausible. Selecting an appropriate field site for research with GM mosquitoes may be one of the most complex and significant aspects of the research process. Among the key considerations of the process is the need to address ethical, legal, and cultural (ESC) issues. No guidelines have been developed to date for this complicated and sensitive process. In this paper, we describe a site selection process and a set of preliminary considerations for addressing the ESC aspects of a research program involving genetic strategies for the control of mosquitoes as vectors for dengue viruses. These considerations reflect some of the key ESC issues for site selection decisions for research with GM vectors.

Received October 30, 2007. Accepted for publication May 30, 2008.

Acknowledgments: The authors thank Michael Keating for editorial assistance and Emma Cohen and Dilzayn Panjwani for help in finalizing this paper.

Financial support: This work was funded by the Bill & Melinda Gates Foundation’s Grand Challenges in Global Health initiative. JL was funded through the Ethical, Social and Cultural Program for the Grand Challenges in Global Health, and LH and TS were funded through the project "Genetic Strategies for Control of Dengue Virus Transmission," Principal Investigator, Anthony James.

* Address correspondence to James V. Lavery, Centre for Research on Inner City Health, Centre for Global Health Research, Keenan Research Centre, Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario M5B 1W8, Canada. E-mail: jim.lavery{at}utoronto.ca

Authors’ addresses: James V. Lavery, Centre for Research on Inner City Health, Centre for Global Health Research, Keenan Research Centre, Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario M5B 1W8, Canada, E-mail: jim.lavery{at}utoronto.ca. Laura C. Harrington, Department of Entomology, Cornell University, 3138 Comstock Hall, Ithaca, NY, Tel: 607-255-4475, E-mail: lch27{at}cornell.edu. Thomas W. Scott, Department of Entomology, University of California, Davis, CA, Tel: 530-754-4196, Fax: 530-752-1537, E-mail: twscott{at}ucdavis.edu.






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