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Am. J. Trop. Med. Hyg., 78(6), 2008, pp. 946-948
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


Genetic Variability of the 45W Gene Family between Chinese and Mexican Taenia solium

Yadong Zheng, Xuepeng Cai*, Xuenong Luo, Dongfeng Zhang, AND Zhizhong Jing
Key Laboratory of Zoonoses of CAAS, Key Laboratory of Veterinary Parasitology of Gansu Province, State Key Laboratory of Veterinary Etiological Biology, and Lanzhou Veterinary Research Institute, CAAS, Lanzhou, Gansu, China

 

ABSTRACT

Taenia solium 45W proteins are good candidates for development of anti-cysticercosis vaccines. However, the genetic characteristics of the 45 gene family are still unclear between different isolates. We investigated the polymorphism of the 45 gene family between Chinese and Mexican T. solium. Alignment showed that TSO45-4B and TSO45-1C antigens were conserved absolutely, whereas other TSO45 proteins varied between these two isolates. It is informative to guide using of recombinant 45W vaccines to control porcine cysticercosis caused by Asiatic or African/ Latin American T. solium.

Received November 27, 2007. Accepted for publication February 9, 2008.

Acknowledgments: The authors are grateful to Prof. D. H. Liu for providing the adult worm and to an anonymous reviewer for critical reading and constructive suggestions.

Financial support: This work was supported by the ‘863’ Program (2006AA10A207) and a Gansu Key Scientific and Technological Grant (2GS063-A43-013), People’s Republic of China.

* Address correspondence to Xuepeng Cai, Lanzhou Veterinary Research Institute, CAAS, Lanzhou, Gansu, 730046 China. E-mail: zhyd9{at}hotmail.com

Authors’ addresses: Yadong Zheng, Xuepeng Cai, Xuenong Luo, Dongfeng Zhang, and Zhizhong Jing, Key Laboratory of Zoonoses of CAAS, Key Laboratory of Veterinary Parasitology of Gansu Province, State Key Laboratory of Veterinary Etiological Biology, and Lanzhou Veterinary Research Institute, CAAS, Xujiaping 1, Yanchangbu, Lanzhou, Gansu 730046, People’s Republic of China, Tel: 86-931-8342535, Fax: 86-931-8340977, E-mails: zhyd9{at}yahoo.com.cn, caixp{at}public.lz.gs.cn, and zhyd9{at}hotmail.com.

Y. Zheng and X. Cai contributed equally to this paper.

Reprint requests: Xuepeng Cai, Xujiaping 1, Yanchangbu, Lanzhou, Gansu 730046, People’s Republic of China, Tel: 86-931-8342535, Fax: 86-931-8340977, E-mails: zhyd9{at}yahoo.com.cn and zhyd9{at}hotmail.com.




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X. Luo, Y. Zheng, J. Hou, S. Zhang, and X. Cai
Protection against Asiatic Taenia solium Induced by a Recombinant 45W-4B Protein
Clin. Vaccine Immunol., February 1, 2009; 16(2): 230 - 232.
[Abstract] [Full Text] [PDF]


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Copyright © 2008 by the American Society of Tropical Medicine and Hygiene.