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Am. J. Trop. Med. Hyg., 78(6), 2008, pp. 1007-1011
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

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Detection of Japanese Encephalitis Virus Antibodies in Bats in Southern China

Jie Cui, Dorian Counor, Di Shen, Guya Sun, Hongxuan He, Vincent Deubel*, AND Shuyi Zhang*
School of Life Science, East China Normal University, Shanghai, China; Emerging Viruses, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China; College of Life Science, Hebei Normal University, Shijiazhuang, China; National Research Center for Wildlife Born Disease, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

In this study, 336 bats of eight species were collected during 2004–2007 in six provinces of Southern China. Antibodies against Japanese encephalitis virus (JEV) were detected by ELISA in 43 of 336 (12.8%) serum samples. Among those ELISA-positive samples, 11 serum samples had neutralizing antibodies against JEV. No JEV was detected in brain and liver samples using specific real-time reverse transcriptase-polymerase chain reaction. This is the first report of JEV neutralizing antibodies in bats in China, which reinforces that bats can be involved in the life cycle of this virus.

Received November 17, 2007. Accepted for publication January 29, 2008.

Acknowledgments: The authors thank Xianchun Tang, Gang Li, Xiaoping Zhang, Qian Yao, and Wei Zhang (College of Life Science, East China Normal University) for capturing bats; Dr Wei Liu (Guangxi CDC) and Dr Guotong Liang (China CDC) for providing information about JEV outbreaks in China; Wei Wang (IPS-CAS) for providing primers and probes for JEV real time RT-PCR; and Dr Caroline Noach-Banet (Kimron Veterinary Institute, Bet Dagan, Israel) for providing WNV RNA for WNV-Ed3 construct.

Financial support: DC is a recipient of the AREVA Foundation. This study was partially supported by State Key Program for Basic Research Grant 2005CB523004 to SZ, Grant 07DZ22940 from the Shanghai government, and the Chinese Academy of Sciences.

* Address correspondence to Vincent Deubel, Emerging Viruses, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China, E-mail: vdeubel{at}sibs.ac.cn; and Shuyi Zhang, School of Life Science, East China Normal University, 3663 North Zhongshan Road, 200062 Shanghai, China, E-mail: syzhang{at}bio.ecnu.edu.cn

Jie Cui and Dorian Counor contributed equally to this paper.

Authors’ addresses: Jie Cui, School of Life Science, East China Normal University, 3663 North Zhongshan Road, 200062 Shanghai, China, and College of Life Science, Hebei Normal University, 113 East Yuhua Road, 050016 Shijiazhuang, China. Dorian Counor, Guya Sun, and Vincent Deubel, Emerging Viruses, Institute Pasteur of Shanghai, Chinese Academy of Sciences, 225 South Chongqing Road, 200025 Shanghai, China. Di Shen, College of Life Science, Hebei Normal University, 113 East Yuhua Road, 050016 Shijiazhuang, China. Hongxuan He, National Research Center for Wildlife Born Disease, Institute of Zoology, Chinese Academy of Sciences, Datun Road, 100101 Beijing, China. Shuyi Zhang, School of Life Science, East China Normal University, 3663 North Zhongshan Road, 200062 Shanghai, China.






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