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Am. J. Trop. Med. Hyg., 78(5), 2008, pp. 833-837
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

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Seoul Virus in Patients and Rodents from Beijing, China

Shu-qing Zuo, Pan-he Zhang, Jia-fu Jiang, Lin Zhan, Xiao-ming Wu, Wen-juan Zhao, Ri-min Wang, Fang Tang, Zhe Dun, AND Wu-chun Cao*
Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China; Center for Disease Control and Prevention of Dongcheng District, Beijing, China; Center for Disease Control and Prevention of Haidian District, Beijing, China

Hemorrhagic fever with renal syndrome (HFRS) is a significant public health problem with an increasing incidence in Beijing, China (report of disease surveillance from the Center for Disease Control and Prevention of Beijing, China). Hantaviruses were detected using RT-PCR method in blood samples of HFRS patients and lung tissues of rodents captured in Beijing. Phylogenetic analyses of 724bp partial S segment of the hantavirus gene showed that the detected Seoul virus (SEOV) fell into three different lineages, two of which circulated in Beijing. A nucleotide sequence identity of 99.7% for one of the cases of HFRS—the human- and Rattus norvegicus-originated SEOV sequences—had only two silent substitutions, suggesting genetic analysis is an essential tool for "case-investigation."

Received April 3, 2007. Accepted for publication January 20, 2008.

Financial support: This research was supported by Natural Science Foundation of Beijing (7021004) and Natural Science Foundation of China (30725032, 30590374, 30771855).

* Address correspondence to Wu-chun Cao, 20 Dong-Da Street, Fengtai District, Beijing, 10071. E-mail: caowc2000{at}yahoo.com.cn

Authors’ addresses: Shu-qing Zuo, Pan-he Zhang, Lin Zhan, Jia-fu Jiang, Xiao-ming Wu, Wen-juan Zhao, Fang Tang, Wu-chun Cao, Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, China, Tel/Fax: (+ 86)10-63896082, E-mail: caowc{at}nic.bmi.ac.cn. Ri-min Wang, Center for Disease Control and Prevention of Dongcheng District, Beijing 100030, China. Zhe Dun, Center for Disease Control and Prevention of Haidian District, Beijing 100027, China.




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W.-Y. Zhang, L.-Q. Fang, J.-F. Jiang, F.-M. Hui, G. E. Glass, L. Yan, Y.-F. Xu, W.-J. Zhao, H. Yang, W. Liu, et al.
Predicting the Risk of Hantavirus Infection in Beijing, People's Republic of China
Am J Trop Med Hyg, April 1, 2009; 80(4): 678 - 683.
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Copyright © 2008 by the American Society of Tropical Medicine and Hygiene.