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Am. J. Trop. Med. Hyg., 78(5), 2008, pp. 729-732
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


Analysis of Naturally Acquired Antibody Responses to the 19-kd C-Terminal Region of Merozoite Surface Protein-1 of Plasmodium vivax from Individuals in Sanliurfa, Turkey

Fadile Yildiz Zeyrek*, Aylin Babaoglu, Seda Demirel, Derya Dirim Erdogan, Mucide Ak, Metin Korkmaz, AND Cevayir Coban
Harran University Medical Faculty, Department of Microbiology, Sanliurfa, Turkey; Ege University Medical Faculty, Department of Parasitology, Izmir, Turkey; The 21st Century COE Combined Program on Microbiology and Immunology, Research Institute for Microbial Diseases and WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan

 

ABSTRACT

Plasmodium vivax is the second most prevalent global Plasmodium species causing malaria after P. falciparum. These two Plasmodium spp. co-exist in most endemic areas, apart from west and central Africa, which has only P. falciparum. However, southeastern Turkey is one of the exceptional regions with the sole presence of P. vivax infection, where a thorough epidemiologic survey has not been performed. Here, we report for the first time the identification of naturally acquired antibodies against the 19-kd C-terminal region of the merozoite surface protein-1 of P. vivax (PvMSP119), using ELISA, from residents in the Sanliurfa region of southeastern Turkey. Among the 82 samples from patients with patent P. vivax malaria, 85% of the individuals were sero-reactive to PvMSP119. Particularly, 69.5% of the subjects were positive for IgM, 53.6% were positive for IgG (predominantly IgG1 and IgG3), and 7.3% were positive for IgA.

Received December 10, 2007. Accepted for publication January 29, 2008.

Acknowledgments: The authors thank Dr. D. Kaslow for the kind gift of recombinant PvMSP119 protein; Prof. Kazuyuki Tanabe and R. Culleton for critical comments on manuscript; the patients who were enrolled in this study; and the members of the National Malaria Control Centers in Siverek, Sanliurfa.

* Address correspondence to Fadile Yildiz Zeyrek, Harran University Medical Faculty, Department of Microbiology, Sanliurfa, Turkey. E-mail: fadilezeyrek{at}hotmail.com

Authors’ addresses: Fadile Yildiz Zeyrek, Harran University Medical Faculty, Department of Microbiology, Sanliurfa, Turkey, Tel: 090-414-3127116, Fax: 090-414-3151181, E-mail: fadilezeyrek{at}hotmail.com. Aylin Babaoglu, Seda Demirel, Derya Dirim Erdogan, Mucide Ak, and Metin Korkmaz, Ege University Medical Faculty, Department of Parasitology, Izmir, Turkey, Tel: 090-232-3904715, Fax: 090-414-3151181. Cevayir Coban, The 21st Century COE, Combined Program on Microbiology and Immunology, Research Institute for Microbial Diseases and WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan, Tel/Fax: 81-6-6879-8301.






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Copyright © 2008 by the American Society of Tropical Medicine and Hygiene.