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Choclo Virus Infection in the Syrian Golden Hamster

Andes virus and Choclo virus are agents of hantavirus pulmonary syndrome. Andes virus in hamsters almost always causes a disease that is pathologically indistinguishable from fatal hantavirus pulmonary syndrome. The purpose of this study was to assess the pathogenicity of Choclo virus in hamsters. None of 18 hamsters infected with Choclo virus exhibited any symptom of disease. No evidence of inflammation or edema was found in the lungs of the 10 animals killed on days 7, 9, 11, 13, and 16 post-inoculation or in the lungs of the 8 animals killed on day 28 post-inoculation; however, hantavirus antigen was present in large numbers of endothelial cells in the microvasculature of the lungs of the animals killed on days 7, 9, 11, and 13 post-inoculation. These results suggest that infection in the microvasculature of lung tissue alone does not result in the life-threatening pulmonary edema in hamsters infected with Andes virus.

Received July 18, 2007. Accepted for publication January 18, 2008.

Acknowledgments: Pierre E. Rollin (Centers for Disease Control and Prevention, Atlanta, GA) kindly provided the rabbit immune serum used in the immunohistochemistry assay. Robert B. Tesh (World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston) provided the polyvalent anti-hantavirus HMAF used in the indirect fluorescent antibody tests. Miguel A. Grimaldo (University of Texas Medical Branch, Galveston) provided logistical support for the work done inside the Shope Laboratory. Cristina Cassetti (National Institutes of Health) facilitated administration of the financial support for this study.

Financial support: This study was financially supported by National Institutes of Health Grants AI-63235 ("Animal models of hantavirus cardiopulmonary syndrome") and AI-67947 ("Viral determinants of hantavirus pulmonary disease in the hamster").

^* Address correspondence to Charles F. Fulhorst, 301 University Blvd., Galveston, TX 77555-0609. E-mail: cfulhors{at}utmb.edu

Authors’ addresses: Eduardo J. Eyzaguirre, University of Texas Medical Branch, Department of Pathology, 301 University Blvd., Galveston, TX 77555-0609, Telephone: 409-772-5548, Fax: 409-747-0060, E-mail: ejeyzagu{at}utmb.edu. Mary Louise Milazzo, Department of Pathology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0609, Telephone: 409-747-2466, Fax: 409-747-2437, E-mail: mamilazz{at}utmb.edu. Frederick T. Koster, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr., SE Albuquerque, NM 87108, Telephone: 505-348-9614, Fax: 505-348-8567, E-mail: fkoster{at}lrri.org. Charles F. Fulhorst, Department of Pathology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0609, Telephone: 409-772-9713, Fax: 409-772-2437, E-mail: cfulhors{at}utmb.edu.