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Am. J. Trop. Med. Hyg., 78(3), 2008, pp. 409-412
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


Intestinal Parasites in Kaposi Sarcoma Patients in Uganda: Indication of Shared Risk Factors or Etiologic Association

Cynthia J. Lin, Edward Katongole-Mbidde, Tadeos Byekwaso, Jackson Orem, Charles S. Rabkin, AND Sam M. Mbulaiteye*
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland; Uganda Cancer Institute, Mulago Hospital, Kampala, Uganda

 

ABSTRACT

Kaposi sarcoma (KS) is endemic in Uganda and shares several risk factors with intestinal parasite infestation, including rural residence, contact with surface water, and walking barefoot, however, the significance of these ecologic relationships is unknown. We investigated these relationships among 1,985 Ugandan patients with cancer. Odds ratios (OR) were calculated using logistic regression. KS patients had higher carriage of Strongyloides stercoralis larvae (OR 2.1, 95% CI 1.2–3.7) and lower carriage of hookworm ova (0.6, 0.4–1.0) and Entamoeba coli cysts (0.7, 0.5–1.0), after adjusting for region of residence, age, gender, and diagnosis. While our findings may be due to confounding, they are compatible with shared risk factors or etiological association between parasites and KS, and warrant well-designed follow up studies.

Received November 8, 2007. Accepted for publication December 15, 2007.

Financial support: This study was funded, in part, through the Intramural Program of the National Cancer Institute, National Institutes of Health, Department of Health and Human Services, contract N02-CO-12400.

* Address correspondence to Sam M. Mbulaiteye, 6120 Executive Boulevard, Executive Plaza South Room 7080, Rockville, MD 20852. E-mail: mbulaits{at}mail.nih.gov

Authors’ addresses: Cynthia J. Lin, Charles S. Rabkin, and Sam M. Mbulaiteye, 6120 Executive Boulevard, Executive Plaza South Room 7080, Rockville, MD 20852, Tel: 301-496-8115, Fax: 301-402-0817, E-mail: mbulaits{at}mail.nih.gov. Edward Katongole-Mbidde, Tadeos Byekwaso, and Jackson Orem, Uganda Cancer Institute, PO Box 3935, Kampala, Uganda, Tel: 256-414-540410.






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Copyright © 2008 by the American Society of Tropical Medicine and Hygiene.