AJTMH ASTMH Job Mart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 78(2), 2008, pp. 217-221
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (4)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rakotonirina, H.
Right arrow Articles by Ménard, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rakotonirina, H.
Right arrow Articles by Ménard, D.
Related Collections
Right arrow Malaria

Accuracy and Reliability of Malaria Diagnostic Techniques for Guiding Febrile Outpatient Treatment in Malaria-Endemic Countries

Hanitra Rakotonirina, Céline Barnadas, Rogelin Raherijafy, Hery Andrianantenaina, Arsène Ratsimbasoa, Laurence Randrianasolo, Martial Jahevitra, Valérie Andriantsoanirina, AND Didier Ménard*
Malaria Unit Research and Epidemiology Unit, Institut Pasteur de Madagascar, BP 1274, Antananarivo 101, Madagascar

The main purpose of this study was to assess the accuracy of various techniques available for diagnosis of malaria. Blood samples were collected from 313 patients with clinical suspicion of uncomplicated malaria in 2 primary health centers in Madagascar. The presence of Plasmodium parasites was assessed by conventional microscopy, 2 rapid diagnostic tests (one HRP2-based test, PALUTOP+4, and one pLDH-based test, OptiMAL-IT), and real-time polymerase chain reaction (PCR), which is used as the "gold standard" method. The degree of agreement observed was very high for microscopy (0.99) and the HRP2-based test (0.93) and high for the pLDH-based test (0.82). Public-health implications are also discussed in this paper.

Received July 10, 2007. Accepted for publication October 17, 2007.

Acknowledgments: The authors thank the Ministry of Health of Madagascar for allowing us access to malaria patients and the patients for participating in the study.

Financial support: This work was supported by the Global Fund Project for Madagascar, Round 3 (Community Action to Roll Back Malaria, grant no. MDG-304-G05-M).

* Address correspondence to Didier Ménard, Institut Pasteur de Madagascar, BP 1274, Antananarivo 101, Madagascar. E-mail: dmenard{at}pasteur.mg

Authors’ addresses: Hanitra Rakotonirina, Céline Barnadas, Rogelin Raherijafy, Hery Andrianantenaina, Martial Jahevitra, Valérie Andriantsoanirina, and Didier Ménard, Malaria Unit Research, Institut Pasteur de Madagascar, BP 1274, Antananarivo 101, Madagascar, Telephone: +261 20 22 412 72, Fax: +261 20 22 415 34, E-mail: dmenard{at}pasteur.mg. Arsène Ratsimbasoa and Laurence Randrianasolo, Epidemiology Unit, Institut Pasteur de Madagascar, BP 1274, Antananarivo 101, Madagascar.




This article has been cited by other articles:


Home page
 Am J Trop Med HygHome page
A. Ratsimbasoa, L. Fanazava, R. Radrianjafy, J. Ramilijaona, H. Rafanomezantsoa, and D. Menard
Evaluation of Two New Immunochromatographic Assays for Diagnosis of Malaria
Am J Trop Med Hyg, November 1, 2008; 79(5): 670 - 672.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by the American Society of Tropical Medicine and Hygiene.