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Am. J. Trop. Med. Hyg., 78(2), 2008, pp. 214-216
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

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Effect of Saccharomyces boulardii in the Treatment of Acute Watery Diarrhea in Myanmar Children: A Randomized Controlled Study

Khin Htwe, Khin Saw Yee, Marlar Tin, AND Yvan Vandenplas*
Department of Child Health, North Okkalapa General Hospital, University of Medicine, Yangon, Myanmar; Universitair Ziekenhuis Brussel Kinderen, Brussels, Belgium

This study was conducted to evaluate the efficacy of Saccharomyces boulardii in acute diarrhea. One hundred hospitalized children in Myanmar (age range = 3 months to 10 years) were included. Fifty were treated with S. boulardii for five days in addition to oral rehydration solution (ORS) and 50 were given ORS alone (control group) in an alternating order. The mean duration of diarrhea was 3.08 days in the S. boulardii group and 4.68 days (P < 0.05) in the control group. Stools had a normal consistency on day 3 in 38 (76%) of 50 patients in the S. boulardii group compared with only 12 (24%) of 50 in the control group (P = 0.019). On day 2, 27 (54%) of 50 had less than three stools per day in the S. boulardii group compared with only 15 (30%) of 50 in the control group (P = 0.019). Saccharomyces boulardii shortens the duration of diarrhea and normalizes stool consistency and frequency. The shortening of the duration of diarrhea results in a social and economic benefits.

Received July 6, 2007. Accepted for publication October 23, 2007.

* Address correspondence to Yvan Vandenplas, Universitair Ziekenhuis Brussel Kinderen, Laarbeeklaan 101, 1090 Brussels, Belgium. E-mail: yvan.vandenplas{at}uzbrussel.be

Authors’ addresses: Khin Htwe, Khin Saw Yee, and Marlar Tin, Department of Child Health, North Okkalapa General Hospital, University of Medicine, Yangon, Myanmar. Yvan Vandenplas, Universitair Ziekenhuis Brussel Kinderen, Laarbeeklaan 101, 1090 Brussels, Belgium, Telephone: 32–2–477–5780, Fax: 32–2–477–5783, E-mail: yvan.vandenplas{at}uzbrussel.be.




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E. C. Dinleyici, M. Eren, Z. A. Yargic, N. Dogan, and Y. Vandenplas
Clinical Efficacy of Saccharomyces boulardii and Metronidazole Compared to Metronidazole Alone in Children with Acute Bloody Diarrhea Caused by Amebiasis: A Prospective, Randomized, Open Label Study
Am J Trop Med Hyg, June 1, 2009; 80(6): 953 - 955.
[Abstract] [Full Text] [PDF]


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Copyright © 2008 by the American Society of Tropical Medicine and Hygiene.