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Prevalence and Genetic Diversities of Hantaviruses in Rodents in Beijing, China

A total of 835 rodents captured in Beijing, China, were tested for hantavirus infection. Fifty-five (6.6%) were positive for viral RNA when lung tissue samples were examined by reverse transcriptase-polymerase chain reaction. Of 666 sera collected from the above rodents, 50 (7.5%) were positive for IgG antibody by ELISA. Among the 50 seropositive rodents, 37 were positive for viral RNA. In addition, five rodents were positive for viral RNA but negative for IgG antibody. The infection rates among study sites (² = 28.93, df = 8, P = 0.001) and habitats (² = 22.88,df = 7, P = 0.02) were significantly different. The sequences of partial M-segment of hantaviruses detected in 11 representative rodents had 0.1–8.2% divergence. Phylogenetic analysis showed that our hantavirus sequences fell into three different lineages regardless of geographical origin or rodent species. A strain detected from a trading center of agricultural products, which might be imported from other provinces, was genetically different from other strains of Beijing.

Received January 25, 2006. Accepted for publication September 10, 2007.

Financial support: This work was funded by Nature Science Foundation of China (30590374) and the Beijing Nature Science Foundation (7021004).

^* Address correspondence to Wu-Chun Cao, 20 Dong-Da Street, Fengtai District, Beijing 10071, China. E-mail: caowc{at}nic.bmi.ac.cn

Authors’ addresses: Jia-Fu Jiang, Shu-Qing Zuo, Wen-Yi Zhang, Xiao-Ming Wu, Fang Tang, Wen-Juan Zhao, Pan-He Zhang, and Wu-Chun Cao, Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, 20 Dong-Da Street, Fengtai District, Beijing 100071, China. Sake J De Vlas, Department of Public Health, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands. Zhe Dun, Haidian Center for Disease Control and Prevention, Beijing 100082, China. Ri-Ming Wang, Dong Cheng Center for Disease Control and Prevention, Beijing 100054, China.

Reprint requests: Wu-Chun Cao, Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, 20 Dong-Da-Jie Street, Fengtai District, Beijing 100071, China, Telephone: 86-10-63896082, Fax: 86-10-63896082, E-mail: caowc{at}nic.bmi.ac.cn or caowc2000{at}yahoo.com.cn.

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