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Am. J. Trop. Med. Hyg., 77(5), 2007, pp. 925-928
Copyright © 2007 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


Relative Susceptibilties of South Texas Mosquitoes to Infection with West Nile Virus

Dana L. Vanlandingham, Charles E. McGee, Kimberly A. Klinger, Nathan Vessey, Chris Fredregillo, AND Stephen Higgs*
Department of Pathology, University of Texas Medical Branch, Galveston, Texas; Harris County Mosquito Control, Houston, Texas

 

ABSTRACT

Three species of mosquitoes (Culex pipiens quinquefasciatus, Aedes aegypti, and Ae. albopictus) collected in Texas were compared with respect to their relative susceptibility to infection with West Nile virus (WNV) strain 114. Oral infection and dissemination rates were 73% infected with 86% dissemination for Ae. aegypti, 13% infected with 100% dissemination for Ae. albopictus, and 100% infected and disseminated for Cx. p. quinquefasciatus. The oral infectious dose required to establish a 50% infection rate was also determined. All feral mosquito species were found to be susceptible to oral infection with WNV (114) in a similar range: Ae. aegypti (6.37 log10 50% tissue culture infectious doses [TCID50]/5 µL), Ae. albopictus (6.17 log10 TCID50/5 µL), and Cx. p. quinquefasciatus (5.33 log10 TCID50/5 µL). These data demonstrate that both Ae. aegypti and Ae. albopictus from Texas are susceptible to infection with WNV at a similar range to Cx. p. quinquefasciatus and may represent a threat of WNV transmission to humans because of host preferences.

Received June 5, 2007. Accepted for publication July 22, 2007.

Acknowledgments: We thank Jing Haung for her expert technical assistance with this project.

Financial support: This study was supported in part by the Centers for Disease Control and Prevention (U50/CCU620539). Dana L. Vanlandingham was supported in part by National Institutes of Health grant T32 A107536. Charles E. McGee was supported by a Centers for Disease Control and Prevention Fellowship Training Program in Vector-Borne Infectious Diseases (TOI/CCT622892).

* Address correspondence to Stephen Higgs, Department of Pathology, University of Texas Medical Branch, Keiller 2.104, 301 University Boulevard, Galveston, TX 77555-0609. E-mail: sthiggs{at}utmb.edu

Authors’ addresses: Dana L. Vanlandingham, Charles E. McGee, Kimberly A. Klinger, and Stephen Higgs, Department of Pathology, University of Texas Medical Branch, Keiller 2.104 L 20762, 301 University Boulevard, Galveston, TX 77555-0609, Telephone: 409-747-2426, Fax: 409-772-2511, E-mail: sthiggs{at}utmb.edu. Nathan Vessey and Chris Fredegill, Harris County Mosquito Control, Harris County Public Health and Environmental Services, 3330 Old Spanish Trail, Building C, Houston, TX 77021, Telephone: 713-440-3025.






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