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Am. J. Trop. Med. Hyg., 77(5), 2007, pp. 903-909
Copyright © 2007 by The American Society of Tropical Medicine and Hygiene

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Laboratory-based Dengue Surveillance in Taiwan, 2005: A Molecular Epidemiologic Study

Jyh-Hsiung Huang, Tsai-Ling Liao, Shu-Fen Chang, Chien-Ling Su, Li-Jung Chien, Yu-Chung Kuo, Cheng-Fen Yang, Chien-Chou Lin, AND Pei-Yun Shu*
Research and Diagnostic Center, Centers for Disease Control, Department of Health, Taipei, Taiwan, Republic of China

We present the results of laboratory-based dengue surveillance in Taiwan for 2005. A phylogenetic study showed that multiple dengue epidemics were caused by three different imported dengue virus (DENV) strains. A strain of DENV-3 (genotype I) imported from the Philippines first appeared in the southern part of Kaohsiung City and later spread to Kaohsiung County from August to December, which resulted in 77 cases of dengue. Another strain of DENV-3 (genotype II) imported from Vietnam first appeared in the central part of Kaohsiung City and later spread to Kaohsiung County from September to December, which resulted in 35 cases of dengue. A strain of DENV-2 (American/ Asian genotype) imported from Vietnam first appeared in Tainan City and later spread to Kaohsiung City/County from October to December, which resulted in 60 cases of dengue. This study provides molecular epidemiologic evidence that most dengue in Taiwan is caused by imported strains of the virus.

Received August 4, 2006. Accepted for publication July 13, 2007.

Acknowledgments: We thank Yu-Chieh Chen, Yun-Yih Chang, and Han Lin for their expert technical assistance, and the staff members of the Gene Sequencing Laboratory, Centers for Disease Control, Department of Health, for performing the sequencing work.

Financial support: This work was supported in part by grants NSC 94-0324-19-F-00-00-00-35 from the National Science Council, and DOH93-DC-2007 from Center for Disease Control, Department of Health, Taiwan, Republic of China.

Disclosure: The authors do not have commercial or other associations that might pose a conflict of interest with this research.

* Address correspondence to Pei-Yun Shu, Research and Diagnostic Center, Centers for Disease Control, Department of Health, 161, Kun-Yang Street, Taipei, Taiwan, Republic of China. E-mail: pyshu{at}cdc.gov.tw

Authors’ address: Jyh-Hsiung Huang, Tsai-Ling Liao, Shu-Fen Chang, Chien-Ling Su, Li-Jung Chien, Yu-Chung Kuo, Cheng-Fen Yang, Chien-Chou Lin, and Pei-Yun Shu, Research and Diagnostic Center, Centers for Disease Control, Department of Health, 161, Kun-Yang Street, Taipei, Taiwan, Republic of China.






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Copyright © 2007 by the American Society of Tropical Medicine and Hygiene.