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Am. J. Trop. Med. Hyg., 77(5), 2007, pp. 825-828
Copyright © 2007 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


Seroprevalence of Entamoeba histolytica Infection in HIV-Infected Patients in China

Yi Chen, Yunzhi Zhang, Bin Yang, Tangkai Qi, Hongzhou Lu, Xunjia Cheng*, AND Hiroshi Tachibana
Department of Medical Microbiology and Parasitology, Fudan University School of Medicine, Shanghai, China; Department of Infectious Diseases, Huashan Hospital Affiliated to Fudan University, Shanghai, China; Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Japan

 

ABSTRACT

Seroprevalence of Entamoeba histolytica infection in HIV-infected individuals from Shanghai city, Anhui province, and Henan province, China, was examined by enzyme-linked immunosorbent assay using crude antigen and a recombinant surface antigen, C-Igl, of the parasite. In 215 HIV-infected individuals, the positive rates for these antigens were 12.1% and 7.9%, respectively; these rates were significantly higher than the rates of 3.1% and 0.5%, respectively, in 191 patients with gastrointestinal symptoms who were not infected with HIV. There was no significant difference in seropositivity to E. histolytica between men and women. Seropositivity in HIV-infected individuals was higher in patients with a CD4+ T cell count of < 200/µL. This is the first report showing a higher seroprevalence of E. histolytica infection in HIV-infected patients in China. Our results also suggest that HIV infection is a risk factor for infection with E. histolytica.

Received March 13, 2007. Accepted for publication July 2, 2007.

Acknowledgments: The authors thank Xiaozhang Pan for his encouragement of this study.

Financial support: This work was supported by a grant from SMHB (2001411), a Grant-in-Aid for Scientific Research from the Japanese Society for the Promotion of Science, and a grant from the Ministry of Health, Labor and Welfare of Japan.

* Address correspondence to Xunjia Cheng, Department of Medical Microbiology and Parasitology, Fudan University School of Medicine, Shanghai 200032, China. E-mail: xjcheng{at}shmu.edu.cn

Authors’ addresses: Yi Chen, Bin Yang, and Xunjia Cheng, Department of Medical Microbiology and Parasitology, Fudan University School of Medicine, Shanghai 200032, China, Telephone: 86-21-5423-7359, Fax: 86-21-5423-7122, E-mail: xjcheng{at}shmu.edu.cn. Yunzhi Zhang, Tangkai Qi, and Hongzhou Lu, Department of Infectious Diseases, Huashan Hospital Affiliated to Fudan University, Shanghai 200041, China, Telephone: 86-21-6248-9999. Hiroshi Tachibana, Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan, Telephone: 81-463-93-1121, Fax: 81-463-95-5450, E-mail: htachiba{at}iss.icc.u-tokai.ac.jp.






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