AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 77(3), 2007, pp. 551-554
Copyright © 2007 by The American Society of Tropical Medicine and Hygiene

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CASE REPORT


Cutaneous Extensively Drug-Resistant Tuberculosis

Douglas P. Olson*, Cheryl L. Day, Nombulelo P. Magula, Faieza Sahid, AND Mahomed-Yunus S. Moosa
Department of Infectious Disease, Division of Medicine, and HIV Pathogenesis Programme, University of KwaZulu Natal, Durban, South Africa; George Washington University School of Medicine, Washington, District of Columbia; Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts

 

ABSTRACT

A 48-year-old immunocompetent man without known exposure to tuberculosis had a > 10-year history of recurrent skin lesions. Cutaneous tuberculosis without any current or past history of pulmonary tuberculosis was diagnosed. Culture of biopsy specimens showed the organism to be resistant to multiple first-line and second-line agents. The patient had a broad, vigorous CD4-specific immune response against multiple tuberculosis antigens. This case is the first report of cutaneous extensively drug-resistant tuberculosis.

Received April 2, 2007. Accepted for publication June 18, 2007.

Financial support: Douglas P. Olson was supported by a Benjamin H. Kean Traveling Fellowship in Tropical Medicine from the American Society of Tropical Medicine and Hygiene.

Disclosure: None of the authors has any conflicts of interest.

* Address correspondence to Douglas P. Olson, Yale University School of Medicine, 26131 Town Walk Drive, Hamden, CT 06518. E-mail: douglas.olson{at}yale.edu

Authors’ addresses: Douglas P. Olson, Yale University School of Medicine, 26131 Town Walk Drive, Hamden, CT 06518, Telephone: 203-376-1926, E-mail: douglas.olson{at}yale.edu. Cheryl L. Day, HIV Pathogenesis Programme, University of KwaZulu Natal, Durban, South Africa and Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129. Nombulelo P. Magula, Faieza Sahid, and M. Yunus Moosa, Department of Infectious Disease, Division of Medicine, University of Kwa-Zulu Natal, Durban, South Africa.






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Copyright © 2007 by the American Society of Tropical Medicine and Hygiene.