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, a well-known virus inhibitor, showed a dose-dependent inhibition of virus replication on Vero cells that was assessed by viral infectivity and viral RNA production. This new real-time RT-PCR was used to measure viral load in serum samples from cases recently imported to Italy, and may be a useful tool in rapid detection of CHIKV and monitoring the extent of viral replication in patients.
Received March 9, 2007. Accepted for publication May 29, 2007.
Acknowledgments: We thank Francesco Fusco, Vincenzo Puro, and Emanuele Nicastri for providing epidemiologic assistance in tracing patient medical histories.
Financial support: The study was partially supported by grants from the Italian Ministry of Health, Fondi Ricerca Corrente, and Piano di Sostegno Diagnostico Assistenziale ed Epidemiologico alle Emergenze Biologiche sul Territorio Italiano.
* Address correspondence to Antonino Di Caro, Laboratory of Virology, Padiglione Baglivi, National Institute for Infectious Diseases L. Spallanzani, Via Portuense 292, 00149 Rome, Italy. E-mail: dicaro{at}inmi.it
Authors addresses: Fabrizio Carletti, Licia Bordi, Roberta Chiappini, Maria R. Sciarrone, Maria R. Capobianchi, Antonino Di Caro, and Concetta Castilletti, Laboratory of Virology, National Institute for Infectious Diseases L. Spallanzani, Rome, Italy, E-mails: carletti{at}inmi.it, lbordi{at}inmi.it, chiappini{at}inmi.it, sciarrone{at}inmi.it, capobianchi{at}inmi.it, dicaro{at}inmi.it, and castilletti{at}inmi.it. Giuseppe Ippolito, Department of Epidemiology, National Institute for Infectious Diseases L. Spallanzani, Rome, Italy, E-mail: ippolito{at}inmi.it.
Reprint requests: Antonino Di Caro Laboratory of Virology, Padiglione Baglivi National Institute for Infectious Diseases L. Spallanzani, Via Portuense 292, 00149 Rome, Italy.
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