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Experience with Intravenous Metronidazole to Treat Moderate-to-Severe Amebiasis in Japan

Twenty-eight cases of either intestinal amebiasis, amebic liver abscess, or both, most of which were of moderate-to-severe intensity, were treated with intravenous metronidazole, pioneered by the Research Group on Chemotherapy of Tropical Diseases, Japan. This study was not conducted as a formal clinical trial, and all patients either underwent colectomy for intestinal amebiasis, received oral metronidazole, or both. Despite these limitations, intravenous metronidazole was shown to be well tolerated and seemed to be very effective. This agent should be more widely recommended than previously thought for treating moderate-to-severe amebiasis, especially its intestinal form.

Received January 17, 2007. Accepted for publication April 13, 2007.

Acknowledgments: We are indebted to all the member physicians of the Research Group on Chemotherapy of Tropical Diseases, Japan, for treating the patients.

Financial support: This study was conducted as a "Research on Health Sciences Focusing on Drug Innovation" (KH42075 and KHA2031) funded by the Japan Health Sciences Foundation.

^* Address correspondence to Mikio Kimura, Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan. E-mail: kimumiki{at}abox3.so-net.ne.jp

Authors’ addresses: Mikio Kimura, Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan, Telephone: 81-3-5285-1111, ext. 2043, Fax: 81-3-5285-1129. Tetsuya Nakamura, Department of Infectious Diseases and Applied Immunology, Institute of Medical Science, University of Tokyo, Shirokanedai 4-6-1, Minato-ku, Tokyo 108-8639, Japan, Telephone: 81-3-5449-5337, Fax: 81-3-5449-5427. Yukifumi Nawa, University of Miyazaki, Gakuen-Kibanadai-Nishi 1-1, Miyazaki 889-2192, Japan, Telephone: 81-985-58-7100, Fax: 81-985-58-2818.

Reprint requests: Mikio Kimura, Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan.