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Confirmation of Elimination of Lymphatic Filariasis by an IgG4 Enzyme-Linked Immunosorbent Assay with Urine Samples in Yongjia, Zhejiang Province and Gaoan, Jiangxi Province, People’s Republic of China

A sensitive and specific IgG4 enzyme-linked immunosorbent assay (ELISA) with urine samples has been reported. To confirm elimination of bancroftian filariasis, the ELISA was used in a study conducted in Yongjia County and Gaoan City, People’s Republic of China, where filariasis elimination was declared, with 10,409 students 5–16 years of age. The antibody positive rates were 0.08% in Yongjia and 0.34% in Gaoan. All positive samples were re-examined and found to be negative. Our results show that this ELISA is practical and useful for confirmation of the elimination of filariasis. If similar results are obtained in different filariasis-endemic countries, this method may be useful in global filariasis elimination programs.

Received January 30, 2006. Accepted for publication February 6, 2007.

Financial support: This study was supported by Grants-in-Aid for Scientific Research (B) no. 14406005 and no. 17406011 from the Japan Society for the Promotion of Science.

^* Address correspondence to Makoto Itoh, Department of Parasitology, Aichi Medical University School of Medicine, Nagakute, Aichiken 480-1195, Japan, E-mail: macitoh{at}aichi-med-u.ac.jp

Authors’ addresses: Makoto Itoh, Mohammad Z. Islam, and Eisaku Kimura, Department of Parasitology, Aichi Medical University School of Medicine, Nagakute, Aichiken 480-1195, Japan, Fax: 81-561-63-3645, E-mails: macitoh{at}aichi-med-u.ac.jp and kimura{at}aichi-med-u.ac.jp. Weiping Wu, Dejian Sun, and Shinan Zhu, Department of Filariasis, Kala-Azar and Hydatidosis, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, People’s Republic of China, E-mails: djsun_1999{at}yahoo.com and wpwu{at}public4.sta.net.cn. Linong Yao, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310009, People’s Republic of China. Zhihong Li and Kunzhao Zhang, Jiangxi Provincial Center for Disease Control and Prevention, Nanchang 330046, People’s Republic of China. Renyu Chen, Wenzhou Center for Disease Control and Prevention, Wenzhou 325000, People’s Republic of China. Fengfei Wang, Gaoan Center for Disease Control and Prevention, Gaoan 330800, People’s Republic of China.