HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Collins, W. E. Articles by Sullivan, J. J. Search for Related Content PubMed PubMed Citation Articles by Collins, W. E. Articles by Sullivan, J. J. Related Collections Drug-Resistance Malaria

Adaptation of a Multi-drug Resistant Strain of Plasmodium falciparum from Peru to Aotus lemurinus griseimembra, A. nancymaae, and A. vociferans Monkeys

A strain of Plasmodium falciparum from Peru was adapted to splenectomized Aotus nancymaae and Aotus vociferans monkeys. The Peru 134/CDC strain of P. falciparum was shown to be resistant to treatment with chloroquine in monkeys and partially resistant to mefloquine and malarone. Genetic mutations in crt, dhfr, dhps, and cytochrome b genes conferring drug resistance were also determined for this Peruvian strain of P. falciparum.

Received March 23, 2007. Accepted for publication April 18, 2007.

Acknowledgments: The authors thank the staff of the Animal Resources Branch, National Center for Preparedness, Detection and Control of Infectious Diseases, for the care of the animals.

Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.

Financial support: This study was supported in part by an Interagency Agreement 936–3100–AA6–P–00–0006–07 between the United States Agency for International Development and the Centers for Disease Control and Prevention. Aliquots of the Peru 01–134/CDC strain of P. falciparum have been deposited with the American Type Culture Collection.

^* Address correspondence to William E. Collins, Mail Stop F–36, Division of Parasitic Diseases, Centers for Disease Control and Prevention, 4770 Buford Highway, Chamblee, GA 30341. E-mail: wec1{at}cdc.gov

Authors’ addresses: W. E. Collins, J. S. Sullivan, Patrice Hall, K. K. Grady, D. Nace, Curtis Huber, J. W. Barnwell, and J. J. Sullivan, Mail Stop F-36, Division of Parasitic Diseases, Centers for Disease Control and Prevention, 4770 Buford Highway, Chamblee, GA 30341, E-mail: wec1{at}cdc.gov. Trenton K. Ruebush II, USAID Bureau for Global Health, 1300 Pennsylvania Avenue, NW, Washington, DC 20523. A. Williams and G. G. Galland, Animal Resources Branch, National Center for Preparedness, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333. A. Bounngaseng and T. Williams, Atlanta Research and Education Foundation, 1670 Clairmont Road, Decatur, GA 30033.