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An Update on Anemia in Less Developed Countries

The highest prevalence of anemia exists in the developing world where its causes are multi-factorial. Anemia is responsible for significant morbidity and mortality, particularly in less developed countries (LDCs). Understanding causes of anemia and potential mechanisms are crucial to our ability to intervene to reduce this burden. In the past decade, our understanding of the etiology and mechanisms of anemia in LDCs has advanced significantly. This review will focus on recent advances in our understanding of the burden of anemia in specific sub-groups, the causes and mechanisms of anemia, and consequences of anemia for the human host.

Received July 26, 2006. Accepted for publication April 13, 2007.

Disclosure: None of the authors has a commercial or other association that might pose a conflict of interest.

^* Address correspondence to Jennifer F. Friedman, Center for International Health Research, Rhode Island Hospital, 55 Claverick Street, Box 3/Suite 101 Providence, RI 02903. E-mail: Jennifer_Friedman{at}Brown.edu

Authors’ addresses: Karine Tolentino, Department of Community Health, Brown University, Providence, RI 02912. Jennifer F. Friedman, Center for International Health Research, Rhode Island Hospital, 55 Claverick Street, Box 3/Suite 101 Providence, RI 02903, Telephone: 401-444-7449, Fax: 401-444-7854, E-mail: jennifer_ friedman{at}Brown.edu.