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Am. J. Trop. Med. Hyg., 76(6), 2007, pp. 1125-1127
Copyright © 2007 by The American Society of Tropical Medicine and Hygiene

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17ß-ESTRADIOL INCREASES LEISHMANIA MEXICANA KILLING IN MACROPHAGES FROM DBA/2 MICE BY ENHANCING PRODUCTION OF NITRIC OXIDE BUT NOT PRO-INFLAMMATORY CYTOKINES

C.M. LEZAMA-DÁVILA*, A.P. ISAAC-MÁRQUEZ, J. BARBI, S. OGHUMU, AND A.R. SATOSKAR*
Department of Microbiology, The Ohio State University, Columbus, Ohio; Dirección de Estudios de Postgrado e Investigación, Universidad Autónoma de Campeche, México

We have previously shown that female DBA/2 mice are significantly more resistant to Leishmania mexicana compared with males. Here, we have analyzed the effect of 17ß-estradiol (E2) on function and cytokine production in male and female DBA/2 macrophages in vitro. We show that E2 increases NO production and parasite killing in L. mexicana-infected male and female DBA/2 macrophages without increasing production of pro-inflammatory cytokines. These data indicate that E2 may enhance leishmanicidal activity in macrophages by directly regulating production of NO.

Received November 3, 2006. Accepted for publication February 27, 2007.

Acknowledgments: Financial support: C.M.L.D. was financially supported by Fundación Pablo Garcia del Estado de Campeche, Mexico. This work received financial support from NIH/NIAID (grant ROI A151823 to A.R.S.).

Disclosure: The authors have no conflicts of interest.

* Address correspondence to C.M. Lezama-Dávila and A.R. Satoskar: Department of Microbiology, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210. E-mails: lezama-davila.1{at}osu.edu and satoskar.2{at}osu.edu

Authors’ addresses: C.M. Lezama-Dávila, J. Barbi, S. Oghumu, and A.R. Satoskar, Department of Microbiology, The Ohio State University, Columbus, OH 43210, Telephone: +1 (614) 292 2816, Fax: +1 (614) 292 8120, E-mail: lezama-davila.1{at}osu.edu. A.P. Isaac-Márquez, Dirección de Estudios de Postgrado e Investigación, Universidad Autónoma de Campeche, México.






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