AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 76(6), 2007, pp. 1016-1018
Copyright © 2007 by The American Society of Tropical Medicine and Hygiene

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CLINICAL CASE REPORT


FALCIPARUM MALARIA WITH HEMOPHAGOCYTIC SYNDROME

KENJI OHNISHI*, KEIKO MITSUI, NOBUHIRO KOMIYA, NORIAKI IWASAKI, AKIKO AKASHI, AND YUICHI HAMABE
Department of Infectious Diseases and Tertiary Emergency Medical Center, Tokyo Metropolitan Bokutoh General Hospital, Tokyo, Japan

 

ABSTRACT

A 30-year-old Japanese woman with falciparum malaria was hospitalized because of fever and renal failure, and prolonged anemia was identified despite the eradication of malaria parasites through anti-malaria therapy. Bone marrow aspiration revealed the presence of macrophages with hemophagocytosis, and serum interleukin (IL)-18 and tumor necrosis factor (TNF)-{alpha} levels were high in the anemic phase. Hemophagocytosis was confirmed for at least 3 weeks, and prolonged hemophagocytic syndrome is thought to be one of the causes of prolonged anemia in patients with falciparum malaria.

Received August 7, 2006. Accepted for publication January 24, 2007.

* Address correspondence to Kenji Ohnishi, Department of Infectious Diseases, Tokyo Metropolitan Bokutoh General Hospital, 4-23- 15 Kohtohbashi, Sumida City, Tokyo 130-8575, Japan. E-mail: infection{at}bokutoh-hp.metro.tokyo.jp

Authors’ addresses: Kenji Ohnishi, Keiko Mitsui, and Nobuhiro Komiya, Department of Infectious Diseases, Tokyo Metropolitan Bokutoh General Hospital, 4-23-15 Kohtohbashi, Sumida City, Tokyo 130-8575, Japan. E-mail: infection{at}bokutoh-hp.metro.tokyo.jp. Noriaki Iwasaki, Akiko Akashi, and Yuichi Hamabe, Tertiary Emergency Medical Center, Tokyo Metropolitan Bokutoh General Hospital, 4-23-15 Kohtohbashi, Sumida City, Tokyo 130-8575, Japan.






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Copyright © 2007 by the American Society of Tropical Medicine and Hygiene.