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Am. J. Trop. Med. Hyg., 76(5), 2007, pp. 964-966
Copyright © 2007 by The American Society of Tropical Medicine and Hygiene

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ACUTE NEUROSCHISTOSOMIASIS: TWO CASES ASSOCIATED WITH CEREBRAL VASCULITIS

STÉPHANE JAURÉGUIBERRY*, SÉVERINE ANSART, LUCIA PEREZ, MARTIN DANIS, FRANÇOIS BRICAIRE, AND ERIC CAUMES
Department of Infectious and Tropical Disease, Hôpital Tenon, Assistance Publique Hopitaux de Paris, Paris, France; Department of Infectious and Tropical Disease and Parasitology-Mycology, Hôpital Pitié-Salpêtrière, Assistance Publique Hopitaux de Paris, Paris, France

Encephalitis and focal neurologic deficits can occur during the acute phase of schistosomiasis. We report two cases in which cerebral imaging showed cerebral vasculitis located in arterial junctional territories. These neurologic complications may be caused by eosinophil-mediated toxicity. Immediate treatment should consist of corticosteroids rather than specific antischistosomal drugs, which may aggravate the disorders.

Received August 7, 2006. Accepted for publication December 28, 2006.

* Address correspondence to Stéphane Jauréguiberry, Service des Maladies Infectieuses et Tropicales, Assistance Publique Hopitaux de Paris, Hôpital Tenon 4 Rue de la Chine, 75020 Paris. E-mail: stephane.jaureguiberry{at}tnn.aphp.fr

Authors’ addresses: Stéphane Jauréguiberry, Service des Maladies Infectieuses et Tropicales, Assistance Publique Hopitaux de Paris, Hôpital Tenon, 4 Rue de la Chine, 75020 Paris, France, Telephone: 33-1-56-01-74-13, E-mail: stephane.jaureguiberry{at}tnn.aphp.fr. Séverine Ansart, Service de Maladies Infectieuses, Center Hospitalier Universitaire Cavale Blanche, 29609 Brest, France, Telephone: 33-2-98-34-71-91, E-mail: sansart{at}chu-brest.fr. Lucia Perez, Service de Médecine Polyvalente Unité 53, Center Hospitalier du Mans, 194 Avenue Rubillard, 72000 Le Mans, France, Telephone: 33-2-43-43-25-27, E-mail: lucia.perez{at}infonia.fr. Martin Danis, François Bricaire and Eric Caumes, Service des Maladies Infectieuses et Tropicales, Assistance Publique Hopitaux de Paris, Hôpital Pitié Salpétrière, 47–83 Boulevard de l’Hôpital, 75013 Paris, France, Telephone: 33-1-42-16-01-14, E-mails: martin.danis{at}psl.aphp.fr, francois.bricaire{at}psl.aphp.fr, and eric.caumes{at}psl.aphp.fr.




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Copyright © 2007 by the American Society of Tropical Medicine and Hygiene.