AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 76(4), 2007, pp. 785-790
Copyright © 2007 by The American Society of Tropical Medicine and Hygiene

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DHORI VIRUS (ORTHOMYXOVIRIDAE: THOGOTOVIRUS) INFECTION IN MICE: A MODEL OF THE PATHOGENESIS OF SEVERE ORTHOMYXOVIRUS INFECTION

ROSA I. MATEO, SHU-YUAN XIAO, HAO LEI, AMELIA P. A. TRAVASSOS DA ROSA, AND ROBERT B. TESH*
Departments of Pathology and of Internal Medicine and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas

After intranasal, subcutaneous, or intraperitoneal infection with Dhori virus (DHOV), adult mice developed a fulminant and uniformly fatal illness with many of the clinical and pathologic findings seen in mice infected with H5N1 highly pathogenic avian influenza A virus. Histopathologic findings in lungs of DHOV-infected mice consisted of hemorrhage, inflammation, and thickening of the interstitium and the alveolar septa and alveolar edema. Extra-pulmonary findings included hepatocellular necrosis and steatosis, widespread severe fibrinoid necrosis in lymphoid organs, marked lymphocyte loss and karyorrhexis, and neuronal degeneration in brain. Similar systemic histopathologic findings have been reported in the few fatal human H5N1 cases examined at autopsy. Because of the relationship of DHOV to the influenza viruses, its biosafety level 2 status, and its similar pathology in mice, the DHOV-mouse model may offer a low-cost, relatively safe, and realistic animal model for studies on the pathogenesis and management of H5N1 virus infection.

Received October 17, 2006. Accepted for publication December 22, 2006.

Acknowledgments: The authors thank Hilda Guzman and Patrick Newman for fine technical assistance and Dora Salinas for help in preparing the manuscript.

* Address correspondence to Robert B. Tesh, Department of Pathology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0609. E-mail rtesh{at}utmb.edu

Authors’ addresses: Rosa I. Mateo, Shu-Yuan Xiao, Hao Lei, Amelia P.A. Travassos da Rosa, and Robert B. Tesh, Department of Pathology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0609. E-mail rtesh{at}utmb.edu.




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G. Li, N. Wang, H. Guzman, E. Sbrana, T. Yoshikawa, C.-t. Tseng, R. B. Tesh, and S.-Y. Xiao
Dhori Virus (Orthomyxoviridae: Thogotovirus) Infection of Mice Produces a Disease and Cytokine Response Pattern Similar to That of Highly Virulent Influenza A (H5N1) Virus Infection in Humans
Am J Trop Med Hyg, April 1, 2008; 78(4): 675 - 680.
[Abstract] [Full Text] [PDF]


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