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VASCULAR ENDOTHELIAL GROWTH FACTOR IS ASSOCIATED WITH BLOOD BRAIN BARRIER DYSFUNCTION IN EOSINOPHILIC MENINGITIS CAUSED BY ANGIOSTRONGYLUS CANTONENSIS INFECTION

Vascular endothelial growth factor (VEGF) is a potent vascular permeability factor and a mediator of brain edema. To assess the role of vascular endothelial growth factor in eosinophilic meningitis, vascular endothelial growth factor was measured in the cerebrospinal fluid (CSF) and blood of 9 patients with eosinophilic meningitis in a cohort study. VEGF_CSF was detected in 8 (90%) of 9 eosinophilic meningitis patients (range, 45–2190 pg/mL) at presentation. The mean VEGF_CSF at presentation, 1 week, and 2 weeks after admission was 568 pg/mL, 751 pg/mL, and 1031 pg/mL, respectively. There was an association between VEGF_CSF, CSF protein, white cell count, and eosinophil counts. The VEGF_SERUM fluctuated during the 6-month follow-up period. These results indicate that vascular endothelial growth factor may be associated with blood-brain barrier disruption in patients with eosinophilic meningitis.

Received July 29, 2006. Accepted for publication December 5, 2006.

Acknowledgment: This work is supported by Grant VGHKS94-020 and VGHKS95-014 from Kaohsiung Veterans General Hospital, Taiwan.

^* Address correspondence to Professor Chuan-Min Yen, Department of Parasitology, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan, Republic of China. E-mail: hctsai1011{at}yahoo.com.tw

Authors’ addresses: Hung-Chin Tsai, Yung-Ching Liu, and Susan Shin-Jung Lee, Section of Infectious Diseases and Department of Medicine, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Road, Kaohsiung, 813, Taiwan, Telephone: 886-7-3468299, Fax: 886-7-3468292. Eng-Rin Chen and Chuan-Min Yen, Department of Parasitology, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan, Telephone: 886-7-3121101 ext. 2169.

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