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Am. J. Trop. Med. Hyg., 76(2), 2007, pp. 392-395
Copyright © 2007 by The American Society of Tropical Medicine and Hygiene

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COMPARISON OF IVERMECTIN AND BENZYL BENZOATE LOTION FOR SCABIES IN NIGERIAN PATIENTS

HALIMA M. SULE AND TOM D. THACHER*
Department of Family Medicine, Jos University Teaching Hospital, Jos, Nigeria

Few studies have compared ivermectin directly with topical agents in developing countries. We compared the effectiveness of oral ivermectin (200 µg/kg) with topical 25% benzyl benzoate and monosulfiram soap in 210 subjects of age 5 to 65 years with scabies. Subjects with persistent lesions after 2 weeks received a second course of treatment. All lesions had resolved after 2 weeks in 77 of 98 (79%) subjects treated with ivermectin and in 60 of 102 (59%) subjects treated topically (P = 0.003). The improvement in severity score was greater in the ivermectin group than in the topical treatment group (P < 0.001). The overall cure rate after 4 weeks was 95% in the ivermectin group and 86% in the topical treatment group (P = 0.04). Compared with topical benzyl benzoate and monosulfiram in the treatment of scabies, ivermectin was at least as effective and led to more rapid improvement.

Received March 28, 2006. Accepted for publication November 2, 2006.

Acknowledgment: This work was submitted as a dissertation in part fulfillment of the Fellowship in General Medical Practice of the National Postgraduate Medical College of Nigeria.

Financial support: This study was funded in part by a dissertation grant of the Jos University Teaching Hospital. The funding agency had no role in the conduct of the study or the decision to publish the results. The American Society of Tropical Medicine and Hygiene (ASTMH) assisted with publication expenses.

* Address correspondence to Tom D. Thacher, Department of Family Medicine, Jos University Teaching Hospital, PMB 2076, Jos, Nigeria. E-mail: tom{at}thachers.org

Authors’ addresses: Halima M. Sule and Tom D. Thacher, Department of Family Medicine, Jos University Teaching Hospital, PMB 2076, Jos, Nigeria, Telephone: +234-73-452355, Fax: +234-73-455038, E-mail: tom{at}thachers.org, haltsav{at}yahoo.com.






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Copyright © 2007 by the American Society of Tropical Medicine and Hygiene.