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Am. J. Trop. Med. Hyg., 76(2), 2007, pp. 318-323
Copyright © 2007 by The American Society of Tropical Medicine and Hygiene

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HUMAN INFECTION AND RISK OF TRANSMISSION OF CHAGAS DISEASE IN HIDALGO STATE, MEXICO

MARCO A. BECERRIL-FLORES*, EDUARDO RANGEL-FLORES, JOSÉ LUIS IMBERT-PALAFOX, JUAN VICENTE GÓMEZ-GÓMEZ, AND ANA HILDA FIGUEROA-GUTIÉRREZ
Area Academica de Medicina, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Hidalgo, Mexico

New zones with risk of infection for Chagas disease were reported in San Antonio Tezoquipan, Caltimacan, and El Ahorcado in the Hidalgo State of Mexico. Antibodies to Trypanosoma cruzi were detected by enzyme-linked immunosorbent assay and indirect hemagglutination assay in human serum samples. Study subjects were also given an electrocardiogram. Trypanosoma cruzi was isolated from triatomines collected and its virulence was determined in BALB/c mice. Seropositive persons were found in the three regions studied and seroprevalence of T. cruzi ranged between 3.25% and 5.13%. Six of eight seropositive persons had cardiac alterations. The species of triatomines detected were Triatoma barberi, Triatoma mexicana, and Triatoma dimidiata, and at least one of each species was infected with T. cruzi. Entomologic indexes from the zones were determined, and El Ahorcado showed the greatest risk of infection. In this region, we found more virulent isolates of T. cruzi in Triatoma barberi, and the highest human seroprevalence for T. cruzi.

Received October 31, 2005. Accepted for publication October 24, 2006.

Acknowledgments: We thank Q. Patricia Gonzalez and Q. Rocío Guzman for technical support in the laboratory and assistance in fieldwork, Dr. Rafael Saavedra Durán, C. Jorge Luis de la Rosa, and Maria De la Luz Martínez Rodriguez for assistance in writing the manuscript.

Financial support: This work was supported by the Consejo Nacional de Ciencia y Tecnología (grant J 33323-M).

* Address correspondence to Marco A. Becerril-Flores, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Carretera Actopan-Tilcuautla, Exhacienda de la Concepción S/N, Hidalgo, Mexico. E-mail: becerril{at}uaeh.reduaeh.mx

Authors’ address: Marco A. Becerril-Flores, Eduardo Rangel-Flores, José Luis Imbert-Palafox, Juan Vicente Gómez-Gómez and Ana Hilda Figueroa-Gutiérrez, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Carretera Actopan-Tilcuautla, Exhacienda de la Concepción S/N, Hidalgo, Mexico, Telephone: 52-771-7172000 extension 5107, Fax: 52-771-7172000 extension 5111, E-mail: becerril{at}uaeh.reduaeh.mx.

Reprint requests: Marco A. Becerril-Flores, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Carretera Actopan-Tilcuautla, Exhacienda de la Concepción S/N, Hidalgo, Mexico.






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Copyright © 2007 by the American Society of Tropical Medicine and Hygiene.