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LONGITUDINAL SURVEY OF KNOCKDOWN RESISTANCE TO PYRETHROID (KDR) IN MALI, WEST AFRICA, AND EVIDENCE OF ITS EMERGENCE IN THE BAMAKO FORM OF ANOPHELES GAMBIAE S.S.

Studies aimed at monitoring the spread of knockdown resistance to pyrethroids (kdr) in time and space are particularly useful for detecting barriers to gene flow among the chromosomal and molecular forms of Anopheles gambiae. We used a recently developed polymerase chain reaction assay to estimate changes in kdr frequency that occurred in several mixed-form populations from Mali, West Africa, in the past decade. We found that the kdr allele significantly increased in frequency in most populations but was still absent from the M molecular form. Importantly, within the S molecular form, kdr was detected for the first time in the Bamako chromosomal form. These results provide important insights on the patterns of spread and emergence of pyrethroid knockdown resistance in West Africa.

Received December 19, 2005. Accepted for publication February 6, 2006.

Financial support: This project was supported by NIAID/NIH Grant AI40308 to G.C.L.

^* Address correspondence to Frederic Tripet, Center for Applied Entomology and Parasitology, School of Life Sciences, Keele University, Staffordshire ST5 5BG, UK. E-mail: f.tripet{at}biol.keele.ac.uk

Authors’ addresses: Frederic Tripet, Jennifer Wright, Claudio Meneses, Lisa Reimer, Michel Slotman, Tara Thiemann, and Gregory Lanzaro, Department of Entomology, University of California Davis, 1 Shields Avenue, Davis, CA 95616-8584. Anthon Cornel and Rory McAbee, Department of Entomology, University of California Davis, 9240 S Riverbend Avenue, Parlier, CA 93648. Abdrahamane Fofana, Guimogo Dolo, and Sekou Traoré, Malaria Research and Training Center, FMPOS. BP: 1805, Point G. Bamako, Mali. Michel Slotman (current address), Department of Ecology and Evolutionary Biology, Yale University, 165 Prospect Street, New Haven, CT 06511. Frederic Tripet (current address), Center for Applied Entomology and Parasitology, School of Life Sciences, Keele University, Staffordshire ST5 5BG, UK.

Reprint requests: Frederic Tripet, Center for Applied Entomology and Parasitology, School of Life Sciences, Keele University, Staffordshire ST5 5BG, UK. E-mail: f.tripet{at}biol.keele.ac.uk.

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