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Am. J. Trop. Med. Hyg., 76(1), 2007, pp. 155-164
Copyright © 2007 by The American Society of Tropical Medicine and Hygiene

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COMPARATIVE PATHOLOGY OF NORTH AMERICAN AND CENTRAL AFRICAN STRAINS OF MONKEYPOX VIRUS IN A GROUND SQUIRREL MODEL OF THE DISEASE

ELENA SBRANA, SHU-YUAN XIAO, PATRICK C. NEWMAN, AND ROBERT B. TESH*
Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas

The first human cases of monkeypox (MPX) were recognized in central Africa in 1970. Since then, sporadic outbreaks of the disease have occurred in central and west Africa. In 2003, an outbreak of human MPX occurred in the United States after importation of infected rodents from west Africa. Clinical features of the 2003 outbreak were less severe than accounts of the disease among people in central Africa. The reasons for this observed difference are unknown. In this study, the clinical and pathologic characteristics of experimental infection with representative central African and North American MPX virus strains were compared in a ground squirrel model of the disease. The results indicate that the US 2003 virus, which phylogenetically is a member of the west African MPX virus clade, was less virulent than central African MPX virus strains.

Received June 29, 2006. Accepted for publication September 26, 2006.

Acknowledgments: We thank Hilda Guzman for technical assistance and Dora Salinas for assistance in preparing the manuscript.

Financial support: This work was supported by contracts NO1-AI25489 and NO1-AI30027 and grant U54-AI57156 from the National Institutes of Health.

* Address correspondence to Robert B. Tesh, Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0609. E-mail: rtesh{at}utmb.edu

Authors’ address: Elena Sbrana, Shu-Yuan Xiao, Patrick C. Newman, and Robert B. Tesh, Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0609, Telephone: 409-747-2431, Fax: 409-747-2429, E-mail: rtesh{at}utmb.edu.




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 Am J Trop Med HygHome page
E. SBRANA, R. JORDAN, D. E. HRUBY, R. I. MATEO, S.-Y. XIAO, M. SIIRIN, P. C. NEWMAN, A. P. A. T. DA ROSA, and R. B. TESH
EFFICACY OF THE ANTIPOXVIRUS COMPOUND ST-246 FOR TREATMENT OF SEVERE ORTHOPOXVIRUS INFECTION
Am J Trop Med Hyg, April 1, 2007; 76(4): 768 - 773.
[Abstract] [Full Text] [PDF]


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Copyright © 2007 by the American Society of Tropical Medicine and Hygiene.