AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 75(5), 2006, pp. 827-829
Copyright © 2006 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


SEVERE PLASMODIUM FALCIPARUM MALARIA IN CAMEROON: ASSOCIATED WITH THE GLUTATHIONE S-TRANSFERASE M1 NULL GENOTYPE

REGINALD A. KAVISHE, JAN B. KOENDERINK*, MATTHEW B.B. MCCALL, WILBERT H.M. PETERS, BERT MULDER, CORNELUS C. HERMSEN, ROBERT W. SAUERWEIN, FRANS G.M. RUSSEL, AND ANDRE J.A.M. VAN DER VEN
Departments of Pharmacology and Toxicology, Medical Microbiology, Gastroenterology, Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Kilimanjaro Christian Medical College of Tumaini University, Tanzania.

 

ABSTRACT

Glutathione S-transferases (GST) are a family of enzymes involved in phase-II detoxification of endogenous and xenobiotic compounds. Polymorphisms in GST genes have been associated with susceptibility to different diseases. In this study we determined the frequencies of polymorphisms in GSTM1, GSTT1, and GSTP1 in DNA of 138 children from Cameroon, presenting with uncomplicated malaria (N = 19), malaria with minor complications (N = 81), or severe malaria (N = 38). Analyses of GSTM1 and GSTT1 were performed using PCR-multiplex procedure, while GSTP1 was done by PCR-RFLP. Subjects presenting with malaria with complications were found more often of the GSTM1-null genotype (58–64%) as compared with those with uncomplicated malaria (32%), a difference that was statistically significant. We conclude that the GSTM1-null genotype is associated with malaria with complications.

Received March 21, 2006. Accepted for publication July 5, 2006.

Acknowledgments: The authors thank Rene te Morsche and Hennie Roelofs for their help with genotyping.

Financial support: Reginald A. Kavishe is supported by NWO-WOTRO (WIZ93-465) through PRIOR.

* Address correspondence to Jan B. Koenderink, Department of Pharmacology and Toxicology 149, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. E-mail: J.Koenderink{at}ncmls.ru.nl

Authors’ addresses: Reginald A. Kavishe, Jan B. Koenderink, Frans G.M. Russel, Department of Pharmacology and Toxicology 149, Radboud University, Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Matthew B.B. McCall, Bert Mulder, Cornelus C. Hermsen, Robert W. Sauerwein, Department of Medical Microbiology 268, Radboud University, Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Wilbert H.M. Peters, Department of Gastroenterology 455, Radboud University, Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Andre J.A.M. van der Ven, Department of Internal Medicine 463, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.






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Copyright © 2006 by the American Society of Tropical Medicine and Hygiene.