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Am. J. Trop. Med. Hyg., 75(4), 2006, pp. 749-752
Copyright © 2006 by The American Society of Tropical Medicine and Hygiene

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*2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN
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SHORT REPORT


2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) REDUCES LEISHMANIA MAJOR BURDENS IN C57BL/6 MICE

OWEN J. BOWERS, KIRSA B. SOMMERSTED, RYAN T. SOWELL, GRETCHEN E. BOLING, WILLIAM H. HANNEMAN, RICHARD G. TITUS, AND GREGORY K. DEKREY*
Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, Colorado; Department of Biological Sciences, College of Natural and Health Sciences, University of Northern Colorado, Greeley, Colorado; Department of Immunology, University of Texas, Graduate School of Biomedical Sciences at Houston, Houston, Texas; Department of Environmental and Radiological Health Sciences and Department of Microbiology, Immunology and Pathology, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, Colorado

 

ABSTRACT

Acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can suppress adaptive immunity. In this study, pre-exposure of Leishmania major–infected mice to TCDD caused a dose-dependent and unexpected decrease in parasite burdens on day 20 after infection. In contrast, TCDD-mediated lymphoid atrophy, suppressed antibody levels, and enhanced interleukin-2 production were observed as expected. These results suggest that TCDD may enhance resistance to L. major in the face of immune suppression.

Received October 4, 2005. Accepted for publication May 24, 2006.

Financial support: This work was supported by the University of Northern Colorado, Colorado State University, and Public Health Service Grant 29955.

* Address correspondence to Gregory K. DeKrey, School of Biological Sciences, College of Natural and Health Sciences, University of Northern Colorado, 501 20th Street, Greeley, CO 80639. E-mail: gregory.dekrey{at}unco.edu

Authors’ addresses: Owen J. Bowers, Division of Infectious Diseases, School of Medicine, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80126, Telephone: 303-315-3558, Fax: 303-315-8054, E-mail: owen.bowers{at}UCHSC.edu. Kirsa B. Sommersted, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523-1682, Telephone 970-491-2357, E-mail: kirsa{at}prodigy.net. Ryan T. Sowell, Department of Immunology, University of Texas, Graduate School of Biomedical Sciences at Houston, 6767 Bertner Ave., Houston, TX 77225-0334, Telephone: 303-847-7398, E-mail: rsa7469{at}gmail.com. Gretchen E. Boling, Department of Biological Sciences, College of Arts and Sciences, University of Northern Colorado, 501 20th Street, Greeley, CO 80639, Telephone: 970-351-2921, Fax: 970-351-2335, E-mail: laxcapt21{at}hotmail.com. William H. Hanneman, Department of Environmental and Radiological Health Sciences, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523, Telephone: 970-491-8635, Fax: 970-491-7569, E-mail: hanneman{at}colostate.edu. Richard G. Titus, Department of Microbiology, Immunology and Pathology, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523, Telephone: 970-491-4964, Fax: 970-491-0603, E-mail: richard.titus{at}colostate.edu. Gregory K. DeKrey, School of Biological Sciences, College of Natural and Health Sciences, University of Northern Colorado, 501 20th Street, Greeley, CO 80639, Telephone: 970-351-2493, Fax: 970-351-2335, E-mail: gregory.dekrey{at}unco.edu.






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