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Am. J. Trop. Med. Hyg., 75(4), 2006, pp. 710-715
Copyright © 2006 by The American Society of Tropical Medicine and Hygiene

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MOLECULAR EPIDEMIOLOGY OF DENGUE TYPE 3 VIRUS IN BRAZIL AND PARAGUAY, 2002–2004

VICTOR H. AQUINO*, ELEN ANATRIELLO, PAULA F. GONÇALVES, ELIANA V. DA SILVA, PEDRO F. C. VASCONCELOS, DEUSYLENE S. VIEIRA, WEBER C. BATISTA, MARIA L. BOBADILLA, CYNTHIA VAZQUEZ, MIRIAN MORAN, AND LUIZ T. M. FIGUEIREDO
Laboratório de Virologia, Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-USP, Ribeirão Preto, Brazil; Centro de Pesquisa em Virologia, Faculdade de Medicina de Ribeirão Preto-USP, Ribeirão Preto, Brazil; Instituo Evandro Chagas, Belém-PA; Centro de Pesquisa em Medicina Tropical, Porto Velho-RO, Brazil; Laboratorio Central de Salud Pública, Ministerio de Salud Pública, Asunción, Paraguay

We studied the molecular epidemiology of dengue virus type 3 (DENV-3) in Brazil and Paraguay by analyzing the 5' and 3' untranslated regions (5' and 3'UTRs) and the E protein gene of viruses isolated between 2002 and 2004. Both 5' and 3'UTRs were highly conserved. However, the 3'UTR of two isolates from Brazil contained eight nucleotide deletions compared with the remaining 26 viruses. Phylogenetic analyses suggested that DENV-3 was introduced into Brazil from the Caribbean Islands at least twice and into Paraguay from Brazil at least three times.

Received February 10, 2006. Accepted for publication June 30, 2006.

Financial support: This work was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo Grants 02/08459–8 and 03/03682–3.

* Address correspondence to Victor H. Aquino, Av. do Café, s/n°.-Campus Universitário da USP-Ribeirão Preto-SP-14040-903-Brazil. E-mail: vhugo{at}fcfrp.usp.br

Authors’ addresses: Victor H. Aquino and Paula F. Gonçalves, Laboratório de Virologia, Departamento de Análises Clínicas, Toxicoló gicas e Bromatoló gicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-USP, Ribeirão Preto-SP, Brazil. Elen Anatriello and Luiz T. M. Figueiredo, Centro de Pesquisa em Virologia, Faculdade de Medicina de Ribeirão Preto-USP, Ribeirão Preto-SP, Brazil. Eliana V. da Silva and Pedro F. C. Vasconcelos, Instituo Evandro Chagas, Belém-PA, Brazil. Deusylene S. Viera and Weber C. Batista, Centro de Pesquisa em Medicina Tropical, Porto Velho-RO, Brazil. Maria L. Bobadilla, Cynthia Vazquez, and Mirian Moran, Laboratorio Central de Salud Pública, Ministerio de Salud Pública, Asunció n, Paraguay.






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Copyright © 2006 by the American Society of Tropical Medicine and Hygiene.