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Am. J. Trop. Med. Hyg., 75(3), 2006, pp. 556-562
Copyright © 2006 by The American Society of Tropical Medicine and Hygiene

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CHINESE HERBAL MEDICINE YIN-CHEN-EXTRACT AS AN ADJUNCT TO ANTHELMINTIC ALBENDAZOLE USED AGAINST ANGIOSTRONGYLUS CANTONENSIS-INDUCED EOSINOPHILIC MENINGITIS OR MENINGOENCEPHALITIS

SHIH-CHAN LAI
Department of Parasitology, Chung Shan Medical University, Taiwan

The effects of albendazole and Yin-Chen-Extract co-therapy on Angiostrongylus cantonensis-induced eosinophilic meningitis in BALB/c mice were evaluated. Assay indicators for the therapeutic effect include worm recovery, histopathological score of the fourth ventricle, tissue-type plasminogen activator, urokinasetype plasminogen activator, matrix metalloproteinase-9, cerebrospinal fluid total protein, leukocyte counts, and proinflammatory cytokines. As a result, albendazole and Yin-Chen-Extract co-therapy significantly decreased (P < 0.05) these factors. Although Yin-Chen-Extract may possess pharmacologic activities beneficial to the inhibition of parasite-induced inflammation, many of these hypothetical benefits await scientific testing and confirmation before application. This study suggests that the combination of Yin-Chen-Extract and albendazole has synergistic effects in managing eosinophilic meningitis or eosinophilic meningoencephalitis.

Received January 4, 2006. Accepted for publication April 20, 2006.

Acknowledgments: The author thanks Ke-Min Chen, Shu-Fang Chang, Chiaying Lee, I-Ting Kuan, and Chun-Hsien Wu, Department of Parasitology, Chung Shan Medical University, for assistance in this study.

Address correspondence to Shih-Chan Lai, Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung 402, Taiwan. E-mail: shih{at}csmu.edu.tw

Author’s address: Shih-Chan Lai, Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung 402, Taiwan. E-mail: shih{at}csmu.edu.tw.






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Copyright © 2006 by the American Society of Tropical Medicine and Hygiene.