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Am. J. Trop. Med. Hyg., 75(3), 2006, pp. 475-479
Copyright © 2006 by The American Society of Tropical Medicine and Hygiene

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HDV GENOTYPES IN THE WESTERN BRAZILIAN AMAZON REGION: A PRELIMINARY REPORT

RAYMUNDO PARANÁ*, ALAN KAY, FELIX MOLINET, SEBASTIÃO VIANA, LUCIANO KALABRIC SILVA, JUAN MIGUEL SALCEDO, JOSÉ TAVARES-NETO, CIRLEY LOBATO, MÁRCIO RIOS-LEITE, LUCIANA MATTEONI, ARGEMIRO D’ OLIVEIRA, JR, PEDRO TAUIL, AND CHRISTIAN TRÉPO
Gonçalo Moniz Research Center, Salvador, Brazil; INSERM Unit 271, Université Claude Bernard Lyon 1, IFR 62, Lyon, France; Tropical Medicine Unit, University of Brasilia, Brasilia, Brazil; Government of Acre State-Health Secretariat, Rio Branco, Brazil; Tropical Medicine Center, Porto Velho, Brazil

In Brazil, hepatitis delta virus (HDV) is only reported in Western Amazonia, where severe cases of acute and chronic HDV hepatitis have been described. The study area was chosen in the States of Acre and Rondonia where most cases of hepatitis B virus (HBV)/HDV are reported. From December 2003 to October 2004, 40 HBsAg carriers with anti-HDV IgM were selected. An epidemiologic questionnaire, including demographic and clinical/epidemiologic variables was filled out. HDV amplification and genotyping were performed. Genotype I was detected in 22 patients (55.0%), whereas genotype III was identified in 18 (45.0%). Patients who were infected with genotype I were older (45.1 ± 17.8 years) than patients infected with genotype III (32.8 ± 10.9 years; P = 0.01). No symptoms were reported by 21 (52.5%) patients. Otherwise, 19 (47.5%) had symptoms (fatigue, abdominal pain, weight loss, and decompensated liver disease) that motivated them to seek medical care. Genotype III carriers were more symptomatic, but no statistical significance was achieved. Our preliminary results show that HDV genotypes I and III are present in Brazilian Amazonia and that HDV genotype III is not limited to the Amerindian population.

Received January 29, 2006. Accepted for publication April 7, 2006.

Financial support: This study was supported by post-graduate program association Federal University of Bahia and CAPES/COFECUB Grant 404/02.

* Address correspondence to Raymundo Paraná, Av. Juracy Magalhaes Jr 2096, Sala 510, Salvador, Bahia 41920000, Brazil. E-mail: rparana{at}ufba.br

Authors’ addresses: Raymundo Paraná, Av. Juracy Magalhaes Jr 2096, Sala 510, Salvador, Bahia 41920000, Brazil, Tel: (55) (0) 71 3537810, Fax: (55) (0) 71 3534980; E-mail: unif{at}svn.com.br. Alan Kay and Christian Trépo, INSERM U271, Université Claude Bernard Lyon 1, IFR 62, 151 cours Albert Thomas, 69003, Lyon, France, E-mails: kay{at}lyon.inserm.fr and trepo{at}lyon.inserm.fr. Felix Molinet and Pedro Tauil, Nucleo de Medicina Tropical, University of Brasilia, Campus Universitário, Brasilia-DF 70000000, Brazil, E-mail: tropical{at}unb.br. Sebastião Viana, Government of Acre State-Health Secretariat, avenue Getúlio Vargas 1446, Rio Branco-AC 69908650, Brazil, E-mail: viana{at}senado.gov.br. Luciano Kalabric Silva, José Tavares-Neto, Márcio Rios-Leite, Luciana Matteoni, and Argemiro D’ Oliveira Jr, Gastro-Hepatology Unit, HUPES, Centro de Pesquisa Gonçalo Moniz, rua Pasre Feijo 240, 30 piso, Salvador-BA 40130150, Brazil, E-mail: petmedicina{at}yahoogrupos.com.br. Juan Miguel Salcedo and Cirley Lobato, Centro de medicina Tropical, rua Guaporé 215, Porto Velho-RO 78909350, Brazil, E-mail: unif{at}syn.com.br.






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Copyright © 2006 by the American Society of Tropical Medicine and Hygiene.