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CLONORCHIS SINENSIS INFECTION AND INCREASING RISK OF CHOLANGIOCARCINOMA IN THE REPUBLIC OF KOREA

To evaluate the prevalence and risk factors of Clonorchis sinensis infection, an epidemiologic survey was performed (3,169 residents; age range: 30–87 years; mean age = 59; 1,973 women) in three areas with different mortality rates of cholangiocarcinoma. C. sinensis prevalence was 2.1% in Chuncheon, 7.8% in Chungju, and 31.3% in Haman, where cholangiocarcinoma incidence rate was 0.3, 1.8, and 5.5 per 100,000 persons, respectively. Of the four major risk factors for C. sinensis (male sex, alcohol consumption, raw freshwater fish intake, and area of residence), area was the strongest. Efforts to discourage raw freshwater fish intake, treat egg carriers, and protect water sources from C. sinensis contamination should be strengthened in the Republic of Korea.

Received January 2, 2006. Accepted for publication March 14, 2006.

Acknowledgments: Min Kyung Lim and Young-Hee Ju share first authorship of this manuscript.

Financial support: This study was supported by National Cancer Center Grant 0110250. The work reported in this paper was undertaken during Dr. M. K. Lim’s tenure as a Postdoctoral Fellowship awardee from the International Agency for Research on Cancer.

^* Address correspondence to Hai-Rim Shin, Research Institute for National Cancer Control and Evaluation, National Cancer Center, 809 Madu-dong, Ilsandong-gu, Goyang, Gyeonggi 411-769, Republic of Korea. E-mail: hrshin{at}ncc.re.kr

Authors’ addresses: Min Kyung Lim, Young-Hee Ju, Jin-Kyoung Oh, Hyun-Joo Kong, Seung-Sik Hwang, and Hai-Rim Shin, Research Institute for National Cancer Control & Evaluation, National Cancer Center, 809 Madu-dong, Ilsandong-gu, Goyang, Gyeonggi, 411-769, Republic of Korea. Silvia Franceschi, Infections and Cancer Epidemiology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon cedex 08, France. Sue-Kyung Park, Department of Preventive Medicine, Konkuk University College of Medicine, 322 Danwol-dong, Chungju, Chungbuk, 380-701, Republic of Korea. Sung-Il Cho, Graduate School of Public Health and Institute of Health and Environment, Seoul National University, 28 Yeongeon-dong, Jongno-gu, Seoul 110-799, Republic of Korea. Woon-Mok Sohn, Department of Parasitology and Institute of Health Sciences, Gyeongsang National University College of Medicine, 92 Chiram-dong, Jinju, Gyeongnam, Republic of Korea. Dong-Il Kim, Department of Occupational Medicine, Kangbuk Sam-sung Hospital and Sungkunkwan University, 108 Pyoung-dong, Jongno-gu, Seoul, Republic of Korea. Keun-Young Yoo, Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yeongeon-dong, Jongno-gu, Seoul 110-799, Republic of Ko-rea. Sung-Tae Hong, Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, 28 Yeongeon-dong, Jongno-gu, Seoul 110-799, Republic of Korea.

Reprint requests: Dr. Hai-Rim Shin, Research Institute for National Cancer Control and Evaluation, National Cancer Center, 809 Madu-dong, Ilsandong-gu, Goyang, Gyeonggi 411-769, Republic of Korea. E-mail: hrshin{at}ncc.re.kr.