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Am. J. Trop. Med. Hyg., 74(6), 2006, pp. 1020-1025
Copyright © 2006 by The American Society of Tropical Medicine and Hygiene

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BENEFICIAL EFFECT OF ERYTHROPOIETIN ADMINISTRATION ON MURINE INFECTION WITH TRYPANOSOMA CONGOLENSE

TOMOKO SUZUKI, YOSHIKO YANAGIMOTO UETA, NOBORU INOUE, XUENAN XUAN, HIDEKI SAITOH, AND HIROSHI SUZUKI*
Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan; Chugai Pharmaceutical Co., Ltd., Tokyo, Japan; Department of Developmental and Medical Technology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

The effect of erythropoietin treatment on Trypanosoma congolense infection in mice was studied. Survival rates of mice were dramatically improved by treatment with recombinant human erythropoietin (r-hu-EPO; 5000 U/kg) when infected with 1,000 cells of T. congolense IL3000 (P < 0.05). All the untreated mice infected with T. congolense IL3000 died by day 9 of infection; however, 100%, 50%, and 25% of the mice treated with r-hu-EPO for 8 days survived to day 20, day 40, and day 60 of the parasitical infection, respectively. Anti-8-hydroxy-2'-deoxyguanosine antibody, a biomarker for oxidative damage of DNA, yielded positive reactions in the cytoplasm of the parasites recovered from the mice treated with r-hu-EPO. These results, taken together, indicate that erythropoietin administration is effective for the treatment of T. congolense infection.

Received October 14, 2005. Accepted for publication February 14, 2006.

Acknowledgments: The authors thank S. Fukumoto and M. Okamura for technical assistance. Pacific Edit reviewed the manuscript before submission.

Financial support: This study was supported, in part, by a grant from Special Coordination Fund for Promoting Science and Technology, Ministry of Education, Culture, Sports, Science, Japan.

* Address correspondence to Hiroshi Suzuki, Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi z-13, Inada, Obihiro, Hokkaido 080-8555, Japan. E-mail: hisuzuki{at}obihiro.ac.jp

Authors’ addresses: Tomoko Suzuki, Yoshiko Yanagimoto Ueta, Noboru Inoue, Xuenan Xuan, and Hiroshi Suzuki, Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada, Obihiro, Hokkaido 080-8555, Japan. Hideki Saitoh, Chugai Pharmaceutical Co., Ltd., Kyobashi, Chiyoda-ku, Tokyo, Japan. Hiroshi Suzuki, Department of Developmental and Medical Technology, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, E-mail: hisuzuki{at}obihiro.ac.jp.






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