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Am. J. Trop. Med. Hyg., 74(6), 2006, pp. 1013-1015
Copyright © 2006 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


RESPONSES TO LEISHMANIA DONOVANI IN MICE DEFICIENT IN BOTH PHAGOCYTE OXIDASE AND INDUCIBLE NITRIC OXIDE SYNTHASE

HENRY W. MURRAY*, ZHAOYING XIANG, AND XIAOJING MA
Departments of Medicine and Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York

 

ABSTRACT

Mice deficient in phagocyte oxidase (phox) and inducible nitric oxide synthase (iNOS), which are primary macrophage killing mechanisms, generated tissue granulomas but showed unrestrained Leishmania donovani visceral replication and suboptimal initial responsiveness to antimony treatment. Nevertheless, visceral infection was controlled post-treatment and did not recur. A phox/iNOS-independent macrophage mechanism, which was not triggered by L. donovani, emerges after chemotherapy.

Received December 9, 2005. Accepted for publication February 28, 2006.

Acknowledgments: We thank Drs. M. Dinauer and C. Nathan for providing the phox KO mice and the iNOS and double KO mice, respectively, and Christine Tsai for expert technical assistance.

Financial support: This study was supported by National Institutes of Health grants AI016393 (Henry W. Murray) and AI45899 (Xiaojing Ma).

* Address correspondence to Henry W. Murray, Department of Medicine, Weill Medical College, Box 136, 1300 York Avenue, New York, NY 10021. E-mail: hwmurray{at}med.cornell.edu

Authors’ addresses: Henry W. Murray, Department of Medicine, Weill Medical College, Box 136, 1300 York Avenue, New York, NY 10021, Telephone: 212-746-6330, Fax: 212-746-6332, E-mail: hwmurray{at}med.cornell.edu. Zhaoying Xiang and Xiaojing Ma, Department of Microbiology and Immunology, Weill Medical College, 1300 York Avenue, New York, NY 10021.






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Copyright © 2006 by the American Society of Tropical Medicine and Hygiene.