| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Rates of tuberculosis (TB) in Africa are highest among people infected with HIV. Searching for additional risk factors in a cohort of HIV-infected Ugandan adults, we previously found that a type 2 cytokine bias and eosinophilia were associated with progression to active TB. A possible role for helminth infection was assessed in this study. We analyzed TB incidence in 462 members of this cohort who were screened for filarial infections, gastrointestinal nematodes, and schistosomiasis. Progression to TB was not associated with gastrointestinal nematodes (rate ratio [RR], 1.18; confidence intervals [CIs], 0.66–2.10) or Mansonella perstans (RR, 0.42; CI, 0.13–1.34). A weak association between Schistosoma mansoni infection and TB was found (RR, 1.42; CI, 0.86–2.34); after adjusting for potential explanatory variables and using more stringent diagnostic criteria, the association was strengthened (RR, 2.31; 1.00–5.33). This analysis suggests an effect of S. mansoni infection on progression to active TB among HIV-1–infected Ugandans.
Received September 18, 2005. Accepted for publication December 21, 2005.
Financial support: This study was funded by Wellcome Trust Research Training Fellowship Grant 060116/Z/99/Z to M. Brown. Additional funding for the cohort came from MRC Programme Grant E743.
* Address correspondence to Michael Brown, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom. E-mail: michael.brown{at}lshtm.ac.uk
Authors’ addresses: George Miiro, MRC Unit, Uganda Virus Research Institute, PO Box 49, Entebbe, Uganda, E-mail: george.miiro{at}mrcuganda.org. Peter Nkurunziza, MRC Unit, Uganda Virus Research Institute, PO Box 49, Entebbe, Uganda, E-mail: peter.nkurunziza{at}mrcuganda.org. Christine Watera, MRC Unit, Uganda Virus Research Institute, PO Box 49, Entebbe, Uganda, E-mail: christine.watera{at}mrcuganda.org. Maria Quigley, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom, E-mail maria.quigley{at}npeu.ox.ac.uk. David W. Dunne, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, United Kingdom, E-mail: dd{at}mole.bio.cam.ac.uk. James A. G. Whitworth, Wellcome Trust, 215 Euston Road, London NW1 2BE, United Kingdom, E-mail: jimmy. whitworth{at}wellcome.ac.uk. Alison M. Elliott, MRC Unit, Uganda Virus Research Institute, PO Box 49, Entebbe, Uganda, E-mail: alison.tom{at}infocom.co.ug.
Reprint requests: Michael Brown, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom. E-mail: michael.brown{at}lshtm.ac.uk.
This article has been cited by other articles:
|
|
 |
|
  C. H. King and M. Dangerfield-Cha The unacknowledged impact of chronic schistosomiasis Chronic Illness, March 1, 2008; 4(1): 65 - 79. [Abstract] [PDF]
|
|
|
|
 |
|
 C. J. Lin, E. Katongole-Mbidde, T. Byekwaso, J. Orem, C. S. Rabkin, and S. M. Mbulaiteye Intestinal Parasites in Kaposi Sarcoma Patients in Uganda: Indication of Shared Risk Factors or Etiologic Association Am J Trop Med Hyg, March 1, 2008; 78(3): 409 - 412. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. P. McManus and A. Loukas Current Status of Vaccines for Schistosomiasis Clin. Microbiol. Rev., January 1, 2008; 21(1): 225 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ayash-Rashkovsky, A.-L. Chenine, L. N. Steele, S. J. Lee, R. Song, H. Ong, R. A. Rasmussen, R. Hofmann-Lehmann, J. G. Else, P. Augostini, et al. Coinfection with Schistosoma mansoni Reactivates Viremia in Rhesus Macaques with Chronic Simian-Human Immunodeficiency Virus Clade C Infection Infect. Immun., April 1, 2007; 75(4): 1751 - 1756. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
