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EFFICACY OF PRAZIQUANTEL DURING THE INCUBATION AND INVASIVE PHASE OF SCHISTOSOMA HAEMATOBIUM SCHISTOSOMIASIS IN 18 TRAVELERS

The efficacy of praziquantel started during the incubation period of schistosomiasis has not been studied. Eighteen tourists were infected by Schistosoma haematobium during summer 2003 after bathing once in the same cascade in Mali. We observed the efficacy of praziquantel given at different phases. They received praziquantel at the first consultation, from Days 10 to 15 after exposure in eight asymptomatic patients (Group 1), from Days 28 to 40 in 4 asymptomatic patients (Group 2), and from Days 20 to 39 in 6 patients with acute schistosomiasis (Group 3). All Group 1 patients developed acute schistosomiasis, compared with none of the Group 2 patients (P < 0.004). Among the 10 patients treated during the acute phase, clinical status deteriorated in four cases. Seventeen of the 18 patients developed chronic schistosomiasis. Early praziquantel treatment was thus less effective than later treatment in preventing acute schistosomiasis, while neither treatment effectively prevented chronic schistosomiasis.

Received April 13, 2005. Accepted for publication June 8, 2005.

Acknowledgments: The authors thank A. Datry, M. Thellier, V. Meysonnier, S. Cantiniaux, C. de Roux Serratrice, J. Serratrice, P. J. Willer, P. Hutin, and our nurses for their help caring for these patients.

^* Address correspondence to Lucia Grandière-Pérez, Service médecine polyvalente U53, Centre Hospitalier du Mans, 194 avenue Rubillard, 72000 Le Mans, France. E-mail: lucia.perez{at}infonie.fr

Authors’ addresses: Lucia Grandière-Pérez, Service médecine polyvalente U53, Centre Hospitalier du Mans, 194 avenue Rubillard, 72000 Le Mans, France, Telephone: 00 33 243432527, E-mail: lucia.perez{at}infonia.fr. Séverine Ansart, Service Maladies Infectieuses, Centre Hospitalier Universitaire Cavale Blanche, 29609 Brest, France, Telephone: 00 33 298347191, E-mail: sansart{at}chu-brest.fr. Luc Paris, Alexandra Faussart, Stéphane Jaureguiberry, Jean-Philippe Grivois, Elise Klément, François Bricaire, Martin Danis, and Eric Caumes, Service de Maladies infectieuses et tropicales, Hôpital Pitié-Salpêtrière, 47-83 boulevard de l’Hôpital, 75013 Paris, France, Telephone: 00 33 1 42 16 01 14, Fax: 00 33 1 1 42 16 01 65, E-mails: luc.paris{at}psl.ap-hop-paris.fr, alexandra.faussart{at}psl.ap-hop-paris.fr, stephane.jaureguiberry{at}psl.ap-hop-paris.fr, jean-philippe.grivois{at}psl.ap-hop-paris.fr, elise.klement{at}psl.ap-hop-paris.fr, francois.bricaire{at}psl.ap-hop-paris.fr, martin.danis{at}psl.ap-hop-paris.fr, and eric.caumes{at}psl.ap-hop-paris.fr.

Reprint requests: Pr Eric Caumes, Service de Maladies infectieuses et tropicales, Hôpital Pitié-Salpêtrière, 47-83 boulevard de l’Hôpital, 75013 Paris, France, Telephone: 00 33 1 42 16 01 14, Fax: 00 33 1 1 42 16 01 65, E-mail: eric.caumes{at}psl.ap-hop-paris.fr.

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