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Am. J. Trop. Med. Hyg., 74(4), 2006, pp. 684-691
Copyright © 2006 by The American Society of Tropical Medicine and Hygiene

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VOLUME REPLACEMENT IN INFANTS WITH DENGUE HEMORRHAGIC FEVER/DENGUE SHOCK SYNDROME

NGUYEN THANH HUNG*, NGUYEN TRONG LAN, HUAN-YAO LEI, YEE-SHIN LIN, LE BICH LIEN, KAO-JEAN HUANG, CHIOU-FENG LIN, DO QUANG HA, VU THI QUE HUONG, LAM THI MY, TRAI-MING YEH, JYH-HSIUNG HUANG, CHING-CHUAN LIU, AND SCOTT B. HALSTEAD
Department of Dengue Hemorrhagic Fever, Children’s Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Microbiology and Immunology, Department of Medical Technology, and Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China; Arbovirus Laboratory, Pasteur Institute, Ho Chi Minh City, Vietnam; Department of Pediatrics, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam; Division of Research and Diagnosis, Department of Health, Center for Disease Control, Taipei, Taiwan, Republic of China; Uniformed Services University of the Health Sciences, Bethesda, Maryland

Volume replacement was studied prospectively in 208 infants with dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). The mean volume of intravenous fluid used was 110.4 mL/kg administered over a mean period of 25.8 hours. The mean volumes of intravenous fluid replacement in infants with DSS was significantly higher than in those with non-shock DHF (129.8 mL/kg versus 102.1 mL/kg; P = 0.001). Patients with DSS had significantly higher proportional requirements for dextran and blood transfusions than non-shock infants. Recurrent shock, prolonged shock, and acute respiratory failure were recorded in 8, 6, and 13 patients, respectively. Four patients with DSS died of severe complications. Intravenous fluid replacement with special care to avoid fluid overload requires careful attention to established indications for use of colloidal solutions and blood transfusions. To improve case fatality rates, special efforts need to be directed to infants with DHF/DSS accompanied by severe complications.


Received August 3, 2005. Accepted for publication November 25, 2005.

Acknowledgments: We thank Tran Tan Tram (former Director of the Children’s Hospital No. 1, Ho Chi Minh City) and Chung-Ming Chang (National Health Research Institutes, Taiwan) for help and support during this study. We also thank the doctors and nurses of the Department of Dengue Hemorrhagic Fever, Children’s Hospital No.1 for providing excellent patient care.

Financial support: This study was supported in part grant NHRI-CN-CL9303P from the National Health Research Institutes, Taiwan.

Disclosure: None of the authors have any commercial or other associations that might pose a conflict of interest.

* Address correspondence to Nguyen Thanh Hung, Department of Dengue Hemorrhagic Fever, Children’s Hospital No. 1, 341 Su Van Hanh Street, District 10, Ho Chi Minh City, Vietnam. E-mail: hungdhf{at}hcm.fpt.vn

Authors’ addresses: Nguyen Thanh Hung, Nguyen Trong Lan, and Le Bich Lien, Department of Dengue Hemorrhagic Fever, Children’s Hospital No. 1, Ho Chi Minh City, Vietnam, Telephone: 84-8-927-1119, Fax: 84-8-927-0053, E-mail: hungdhf{at}hcm.fpt.vn. Huan-Yao Lei, Yee-Shin Lin, Kao-Jean Huang, and Chiou-Feng Lin, Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China. Do Quang Ha and Vu Thi Que Huong, Arbovirus Laboratory, Pasteur Institute- Ho Chi Minh City, Vietnam. Lam Thi My, Department of Pediatrics, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam. Trai-Ming Yeh, Department of Medical Technology, Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China. Jyh-Hsiung Huang, Division Of Research and Diagnosis, Department of Health, Center For Disease Control, Taipei, Taiwan, Republic of China. Ching-Chuan Liu, Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China. Scott B. Halstead, Uniformed Services University of The Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799.




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