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Am. J. Trop. Med. Hyg., 74(4), 2006, pp. 674-677
Copyright © 2006 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


MOLECULAR EPIDEMIOLOGY OF HUMAN IMMUNODEFICIENCY VIRUS–INFECTED INDIVIDUALS IN MEDELLIN, COLOMBIA

GLORIA I. SANCHEZ, CHRISTIAN T. BAUTISTA, LINDSAY EYZAGUIRRE, GLADYS CARRION, SONIA ARIAS, WARREN B. SATEREN, MONICA NEGRETE, SILVIA M. MONTANO, JOSE L. SANCHEZ, AND JEAN K. CARR*
Grupo Infección y Cáncer, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia; United States Military HIV Research Program at the Walter Reed Army Institute of Research, and the Henry M. Jackson Foundation for the Advancement Military Medicine, Inc., Rockville, Maryland; Sección de Enfermedades Infecciosas, Departamento de Medicina Interna, Hospital Universitario, San Vicente de Paul, Medellín, Colombia; United States Naval Medical Research Center Detachment, Lima, Peru

 

ABSTRACT

To study the molecular epidemiology of human immunodeficiency virus type 1 (HIV-1) strains in Medellín, Colombia, 115 HIV-1-positive individuals who were recruited from an HIV outpatient hospital (Universitario San Vicente de Paul) during the period from July 2001 to January 2002 were genotyped. All samples were analyzed by envelope heteroduplex mobility assay and found to be subtype B. Twenty-four samples were randomly selected for sequencing of the protease and the reverse transcriptase regions; all isolates were found to be subtype B. Phylogenetic analysis of seven nearly full-length genomes showed that all samples were subtype B. This study shows that the HIV epidemic in Colombia continues to be dominated by the subtype B virus. The predominance of subtype B genotypes of HIV-1 strains in Medellín resembles what is seen in the nearby countries of Peru, Ecuador, and Venezuela.

Received July 11, 2005. Accepted for publication September 13, 2005.

Acknowledgments: This paper is dedicated to the memory of Dr. Gloria Velasquez, who passed away on November 23, 2002, for her lifetime of selfless commitment to the healthcare of patients with HIV/AIDS. We thank Gloria Chauca (U.S. Naval Medical Research Center Detachment, Lima, Peru) for invaluable assistance with sample preparation, transport, and professional guidance, and A. Sebastian for technical assistance.

Disclaimer: The opinions and assertions made by the authors do not necessarily reflect the official position or opinion of the University of Antioquia, U.S. Department of the Army or Navy, or the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

* Address correspondence to Jean K. Carr, U.S. Military HIV Research Program and the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Rockville, MD 20850. E-mail: jcarr{at}hivresearch.org

Authors’ addresses: Gloria I. Sanchez and Sonia Arias, Universidad de Antioquia, Cra 51D, No. 62-29, Medellín, Antioquia, Colombia, Telephone: 57-4-210-6066, Fax: 57-4-263-3509, E-mail: sanchezg{at}ico.scs.es. Christian T. Bautista, Lindsay Eyzaguirre, Warren B. Sateren, José L. Sanchez, and Jean K. Carr, U.S. Military HIV Research Program at the Walter Reed Army Institute of Research, and the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, 1 Taft Court, Suite 250, Rockville, MD 20850, Telephone: 301-251-5033, Fax: 301-294-1898. E-mails: cbautista{at}hivresearch.org, leyzaguirre{at}hivresearch.org, wsateren{at}hivresearch.org, jsanchez{at}hivresearch.org, and jcarr{at}hivresearch.org. Gladys Carrión, Monica Negrete, and Silvia M. Montano, U.S. Naval Medical Research Center Detachment, Lima, Peru. Unit 3800, APO-AA 34031-3800, Telephone: 51-1-561 2733, Fax: 51-1-561 3042, E-mails: gcarrion{at}nmrcd.med.navy.mil, mnegreteg{at}yahoo.com, and smontano{at}nmrcd.med.navy.mil.

Reprint requests: Jean K Carr, U.S. Military HIV Research Program and the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., 1 Taft Court, Suite 250, Rockville, MD 20850, Telephone: 301-251-5033, Fax: 301-294-1898, E-mail: jcarr{at}hivresearch.org.






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