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Am. J. Trop. Med. Hyg., 74(4), 2006, pp. 591-592
Copyright © 2006 by The American Society of Tropical Medicine and Hygiene

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VARICELLA ZOSTER VIRUS MENINGITIS COMPLICATING SODIUM STIBOGLUCONATE TREATMENT FOR CUTANEOUS LEISHMANIASIS

JOSHUA D. HARTZELL*, NAOMI E. ARONSON, SUDHIR NAGARAJA, TIM WHITMAN, CLIFTON A. HAWKES, AND GLENN WORTMANN
Department of Internal Medicine, Walter Reed Army Medical Center, Washington D.C.; Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Neurology, Walter Reed Army Medical Center, Washington, D.C.; Infectious Diseases Division, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Infectious Diseases Service, National Naval Medical Center, Bethesda, Maryland; Infectious Diseases Service, Walter Reed Army Medical Center, Washington, D.C.

Sodium stibogluconate (Pentostam®; GlaxoSmithKline) is a pentavalent antimonial compound used in the treatment of leishmaniasis, which has an association with reactivation of varicella zoster virus (VZV). We report the first known case of an immunocompetent adult who developed VZV aseptic meningitis and dermatomal herpes zoster during treatment with sodium stibogluconate.

Received February 26, 2005. Accepted for publication November 8, 2005.

Disclaimer: The views expressed are those of the authors and should not be construed to represent the positions of Walter Reed Army Medical Center, the Department of the Army, or the Department of Defense.

* Address correspondence to Joshua D. Hartzell, Department of Internal Medicine, 2JO5, Walter Reed Army Medical Center, 6900 Georgia Ave. NW, Washington, D.C. 20307-5001. E-mail: Joshua. hartzell{at}na.amedd.army.mil

Authors’ addresses: Joshua D. Hartzell, Department of Internal Medicine, 2JO5, Walter Reed Army Medical Center, 6900 Georgia Ave. NW, Washington, D.C. 20307-5001, Telephone: 202-782-5584, Fax: 202-782-5813, E-mail: Joshua.hartzell{at}na.amedd.army.mil. Naomi E. Aronson, Leishmaniasis Treatment Center, Infectious Disease Service, Ward 63, Walter Reed Army Medical Center, 6900 Georgia Ave. NW, Washington, D.C. 20307-5001, Telephone: 301-295-6400. Sudhir Nagaraja, Department of Neurology, Ward 61, Walter Reed Army Medical Center, 6900 Georgia Ave. NW, Washington, D.C. 20307-5001, Telephone: 202-782-1661. Tim Whitman, Infectious Diseases Service, National Naval Medical Center, Wisconsin Ave., Bethesda, MD 20814. Clifton A. Hawkes, Infectious Diseases Service, Ward 63, Walter Reed Army Medical Center, 6900 Georgia Ave. NW, Washington, D.C. 20307-5001, Telephone: 202-782-1663. Glenn Wortmann, Infectious Diseases Service, Ward 63, Walter Reed Army Medical Center, 6900 Georgia Ave. NW, Washington, D.C. 20307-5001, Telephone: 202-782-1663.

Reprint requests: Joshua D. Hartzell, Department of Internal Medicine, 2JO5, Walter Reed Army Medical Center, 6900 Georgia Ave. NW, Washington, D.C. 20307-5001, E-mail: Joshua.hartzell{at}na.amedd.army.mil.




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I.-K. Yoon, J. Cox, Y. Zhou, Y. Lukes, B. Reinhardt, A. Valencia-Micolta, and G. Wortmann
Varicella Zoster Virus-Specific Immune Response after Treatment with Sodium Stibogluconate for Cutaneous Leishmaniasis
Am J Trop Med Hyg, March 1, 2008; 78(3): 402 - 405.
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