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Am. J. Trop. Med. Hyg., 74(4), 2006, pp. 536-539
Copyright © 2006 by The American Society of Tropical Medicine and Hygiene

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PREVALENCE OF AND FACTORS ASSOCIATED WITH HELICOBACTER PYLORI INFECTION IN CHILDREN IN THE NORTH OF VIETNAM

BANG V. NGUYEN*, KHANH G. NGUYEN, CAM D. PHUNG, ODILE KREMP, NICOLAS KALACH, CHRISTOPHE DUPONT, JOSETTE RAYMOND, AND GWENAËLLE VIDAL-TRECAN
Pediatric Department, Hanoi Medical University, Hanoi, Vietnam; Digestive Disease Division, National Institute of Epidemiology and Hygiene, Hanoi, Vietnam; Pediatric Department of Saint Antoine, Saint Vincent de Paul Hospital, Catholic University, Lille, France; Neonatology and Gastroenterology Department, Cochin–Saint Vincent de Paul Hospital Group, Faculty of Medicine, Descartes University, Paris, France; Microbiology Department, Cochin–Saint Vincent de Paul Hospital Group, Faculty of Medicine, Descartes University, Paris, France; Public Health Department, Cochin–Saint Vincent de Paul Hospital Group, Faculty of Medicine, Descartes University, Paris, France

The study aimed at evaluating the seroprevalence of and sociodemographic, health, lifestyle, and environmental hygiene conditions associated with Helicobacter pylori infection in Vietnamese children. Data from 824 children, aged from 6 months to 15 years and gastrointestinal symptom free when consulted, admitted to a university hospital, were collected using a structured questionnaire and ELISA test for H. pylori infection. The data were examined using univariate and multivariate analyses. H. pylori seroprevalence was 34.0%. Age groups from 3 to 6 years and older than 6, and number of offspring were positively and independently associated with H. pylori seropositivity [adjusted OR (95% CI): 2.9 (1.5–5.5); 1.9 (1.1–3.1) and 1.8 (1.1–2.6), respectively]. Breastfeeding more than 6 months was negatively and independently associated with H. pylori seropositivity [adjusted OR (95% CI): 0.5 (0.3–0.9)]. Mother’s age, history of allergy, gastro-duodenal disease history in the past, initiating collective life before 6 years, sharing bed with parents and time of bed sharing with parents > 24 months were positively but not independently associated with H. pylori seropositivity. None of the other environmental or lifestyle conditions examined was associated with H. pylori infection. Our results support person-to-person transmission and the role of sociodemographic factors in H. pylori infection.

Received August 6, 2004. Accepted for publication November 14, 2005.

Acknowledgments: We would like to thank Hanoi Medical University and the National Institute of Epidemiology and Hygiene for supporting techniques and materials indispensable for the study; the personnel of the Pediatric Department of Bachmai Teaching Hospital (Hanoi), whose invaluable assistance and primordial involvement in organization and participation makes these findings possible; and our patients and their families participating in the study for their preciously collaborative spirit.

Financial support: This study was supported by the Ministry of Health of Vietnam.

* Address correspondence to Bang V. Nguyen, 299 Giap Bat Street, Hanoi, Vietnam. E-mail: hongbang52{at}yahoo.com

Authors’ addresses: Bang V. Nguyen, 299 Giap Bat Street, Hanoi, Vietnam, Telephone: 84 903293212, E-mail: hongbang52{at}yahoo.com. Khanh G. Nguyen, 18 Hang Hom Street, Hanoi, Vietnam, Telephone: 84 4 8289702, E-mail: nguyengiakhanh1945{at}yahoo.com. Cam D. Phung, Digestive Disease Division, National Institute of Epidemiology and Hygiene, 1 Yersin Street, Hanoi, Vietnam, E-mail: cam{at}fpt.vn. Odile Kremp, Pediatric Department of St Antoine, St Vincent de Paul Hospital, Catholic University, Lille, France, Telephone: 33 3 20877618, E-mail: kremp.odile{at}ghicl.net. Nicolas Kalach, Pediatric Department of St Antoine, St Vincent de Paul Hospital, Catholic University, Lille, France, Telephone: 33 3 20877617, E-mail: kalach.nicolas{at}ghicl.net. Christophe Dupont, Neonatology and Gastroenterology Department, University René Descartes, CHU Cochin–Saint Vincent de Paul, Paris, France, Telephone: 33 1 40488060, E-mail: secretariat.dupont{at}svp.ap-hop-paris.fr. Josette Raymond, Microbiology Department, University René Descartes, CHU Cochin–Saint Vincent de Paul, Paris, France, Telephone: 33140487656, E-mail: j.raymond{at}svp.ap-hop-paris.fr. Gwenaëlle Vidal-Trecan, Public Health Service, University René Descartes, CHU Cochin–Saint Vincent de Paul, Paris, France, Telephone: 33 1 58412646, E-mail: gwenaelle.vidal-trecan{at}univ-paris5.fr.

Reprint requests: Bang V. Nguyen, 299 Giap Bat Street, Hanoi, Vietnam, Telephone: 84 903293212, E-mail: hongbang52{at}yahoo.com.






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