AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 74(3), 2006, pp. 440-443
Copyright © 2006 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


MOLECULAR IDENTIFICATION OF A COLLECTION OF SPOTTED FEVER GROUP RICKETTSIAE OBTAINED FROM PATIENTS AND TICKS FROM RUSSIA

STANISLAV N. SHPYNOV, PIERRE-EDOUARD FOURNIER*, NIKOLAY V. RUDAKOV, IRINA E. SAMOILENKO, TATJANA A. RESHETNIKOVA, VLADIMER K. YASTREBOV, MATVEY S. SCHAIMAN, IRINA V. TARASEVICH, AND DIDIER RAOULT
Unité des Rickettsies, Faculté de Médecine, Marseille, France; Omsk Research Institute of Natural Foci Infections, Omsk, Russia; The Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia

 

ABSTRACT

Thirty-one rickettsial isolates from ticks or patients in North Asian tick typhus (NATT) foci from the Ural region to the Russian Far East were obtained at the Omsk Research Institute of Natural Foci Infections between 1954 and 2001. Using citrate synthase (gltA) and outermenbrane protein a (ompA) gene sequencing, we identified these isolates as Rickettsia sibirica sensu stricto (25 isolates), R. sibirica strain BJ-90 (2 isolates), R. slovaca (1 isolate), and R. heilongjiangensis (3 isolates). We demonstrate that Ixodes persulcatus ticks should be considered potential vectors of NATT. We also demonstrate the presence of R. slovaca in Ural and R. heilongjiangensis in Siberia and Russian Far East, where they may cause human infections misdiagnosed as cases of NATT. Clinicians should be aware that several spotted fever rickettsioses with different prognoses coexist in Russia in areas where NATT was the only previously recognized rickettsiosis.

Received January 10, 2005. Accepted for publication August 25, 2005.

Acknowledgments: We thank Patrick J. Kelly for reviewing the manuscript.

Disclosure: None of the authors has any conflicts of interest related to this research.

* Address correspondence to Pierre-Edouard Fournier, Unité des Rickettsies, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6020, Institut Fédératif de Recherche 48, Université de la Méditerranée, Faculté de Médecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France. E-mail: pierre-edouard.fournier{at}medecine.univ-mrs.fr

Authors’ addresses: Stanislav Shpynov, Unité des Rickettsies, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6020, Institut Fédératif de Recherche 48, Université de la Méditerranée, Faculté de Médecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France and Omsk Research Institute of Natural Foci Infections, 7 Prospect Mira, Omsk 644080, Russia. Pierre-Edouard Fournier and Didier Raoult, Unité des Rickettsies, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6020, Institut Fédératif de Recherche 48, Université de la Méditerranée, Faculté de Médecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France, Telephone: 33-4-91-32-43-75, Fax: 33-4-91-38-77-72, E-mails: pierre-edouard.fournier{at}medecine.univ-mrs.fr and didier.raoult{at}medecine.univ-mrs.fr. Nikolay Rudakov, Irina Samoilenko, Tatjana Reshetnikova, Vladimer Yastrebov, and Matvey Schaiman, Omsk Research Institute of Natural Foci Infections, 7 Prospect Mira, Omsk 644080, Russia, Telephone: 7-381-2-65-14-77 Fax: 7-381-2-65-14-77. Irina Tarasevich, The Gamaleya Research Institute of Epidemiology and Microbiology, 18 Gamaleya Street, Moscow 123098, Russia.






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